- Doravirine
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- $15.00
-
2021-07-13
- CAS:1338225-97-0
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Doravirine
-
- $15.00
-
2021-07-10
- CAS:1338225-97-0
- Min. Order: 1KG
- Purity: 99%+ HPLC
- MK-1439
-
- $20.00
-
2020-11-16
- CAS:1338225-97-0
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 1000KG
Related articles - What is Doravirine？
- Doravirine is a novel nonnucleoside reverse transcriptase inhibitor (NNRTI) currently in development for the treatment of pati....
- Dec 21，2023
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| | Doravirine Basic information |
| Product Name: | Doravirine | | Synonyms: | 3-chloro-5-((1-((4-Methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)Methyl)-2-oxo-4-(trifluoroMethyl)-1,2-dihydropyridin-3-yl)oxy)benzonitrile;3-Chloro-5-[[1-[(4,5-dihydro-4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methyl]-1,2-dihydro-2-oxo-4-(trifluoromethyl)-3-pyridinyl]oxy]benzonitrile;Doravirine / MK-1439;Doravirine;MK-1439(Doravirine);Benzonitrile, 3-chloro-5-[[1-[(4,5-dihydro-4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methyl]-1,2-dihydro-2-oxo-4-(trifluoromethyl)-3-pyridinyl]oxy]-;3-chloro-5-[1-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methyl]-2-oxo-4-(trifluoromethyl)pyridin-3-yl]oxybenzonitrile;MK1439;MK 1439 | | CAS: | 1338225-97-0 | | MF: | C17H11ClF3N5O3 | | MW: | 425.75 | | EINECS: | | | Product Categories: | | | Mol File: | 1338225-97-0.mol |  |
| | Doravirine Chemical Properties |
| Melting point | >278°C (dec.) | | density | 1.56±0.1 g/cm3(Predicted) | | storage temp. | -20°C Freezer | | solubility | DMSO (Slightly, Heated), Methanol (Slightly, Heated) | | form | Solid | | pka | 8.04±0.20(Predicted) | | color | White to Off-White | | InChI | InChI=1S/C17H11ClF3N5O3/c1-25-13(23-24-16(25)28)8-26-3-2-12(17(19,20)21)14(15(26)27)29-11-5-9(7-22)4-10(18)6-11/h2-6H,8H2,1H3,(H,24,28) | | InChIKey | ZIAOVIPSKUPPQW-UHFFFAOYSA-N | | SMILES | C(#N)C1=CC(OC2=C(C(F)(F)F)C=CN(CC3N(C)C(=O)NN=3)C2=O)=CC(Cl)=C1 |
| | Doravirine Usage And Synthesis |
| Uses | Doravirine is a novel non-nucleoside inhibitor of HIV-1 reverse transcriptase with potent activity against wild-type virus. | | in vivo | Administration of 50 mg Doravirine with a high-fat meal is associated with slight elevations in AUC time zero to infinity and C24 h with no change in Cmax[2]. |
| | Doravirine Preparation Products And Raw materials |
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