- Cefpirome sulfate
-
- $34.00 / 500mg
-
2026-04-22
- CAS:98753-19-6
- Min. Order:
- Purity: 99.22%
- Supply Ability: 10g
- Cefpirome sulfate
-
- $1.00 / 1KG
-
2026-03-20
- CAS:98753-19-6
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10mt
- Cefpirome sulfate
-
- $0.00 / 25kg
-
2025-12-01
- CAS:98753-19-6
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 10000KGS
|
| | Cefpirome sulfate Basic information |
| | Cefpirome sulfate Chemical Properties |
| Melting point | 198-2020C (dec) | | alpha | 25D -4.7° (c = 5 in H2O) | | RTECS | UW8970000 | | storage temp. | Inert atmosphere,2-8°C | | solubility | Soluble in DMSO | | form | Solid | | color | White to Off-White | | λmax | 265nm(Buffer)(lit.) | | Merck | 14,1940 | | InChIKey | RKTNPKZEPLCLSF-YBZTWAOJNA-N | | SMILES | S(=O)(O)(O)=O.C(C1CS[C@@H]2[C@H](NC(=O)/C(=N\OC)/C3N=C(N)SC=3)C(=O)N2C=1C(=O)[O-])[N+]1C2CCCC=2C=CC=1 |&1:9,10,r| | | CAS DataBase Reference | 98753-19-6(CAS DataBase Reference) |
| | Cefpirome sulfate Usage And Synthesis |
| Description | Cefpirome sulfate is a new injectable cephalosporin indicated for the treatment of
severe urinary and respiratory tract infections, including septicemia and nosocomial
infections. Cefpirome sulfate is reported to be the first true fourth-generation
cephalosporin due to its similar activities to third-generation antibiotics against
Gram-positive bacteria and to first-generation antibiotics against Gram-negative
bacteria. Its efficacy against P.aeruginosa is comparable to ceftazidime. The broad
spectrum of activity includes Klebsiella, methicillin-sensitive staphylococci,
penicillin-resistant pneumococci, E.coli which generates extended-spectrum
beta-lactamases and multi-resistant organisms such as Citrobacter, Enterobacter and
Serratia. | | Chemical Properties | White Crystalline Powder | | Originator | Hoechst AG (Germany) | | Uses | A fourth generation cephalosporin antibiotic | | Definition | ChEBI: Cefpirome sulfate is an azaheterocycle sulfate salt. It is functionally related to a cefpirome. | | Brand name | Cefrom (Hoechst-Roussel). | | Synthesis | The present invention employs a microwave-assisted synthesis method to synthesize cefpirome hydrogensulfate in the following steps: (1) 7-aminocephalosporanic acid (2.72 g, 0.01 mol, Compound I) was mixed homogeneously with (Z)-S-2-benzothiazolyl-2-amino-alpha-(methoxyimino)-4-thiazole thioacetate (AEMA, 3.85 g, 0.011 mol, Compound VII) was homogeneously mixed and ground, followed by the addition of 2,3-cyclopentenopyridine (2.3 g, 0.011 mol, Compound IV) and concentrated sulfuric acid (10.88 g, 98 wt%). (2) The microwave reaction was carried out sequentially: 300 W for 1 min, 450 W for 1 min and 750 W for 2 min. (3) After completion of the reaction, deionized water (29.92 g) was added to the residue, mixed and filtered, the filtrate was collected and the solvent was removed to obtain a white solid. The resulting solid was dried under vacuum at 50 °C for 4 h. Cefpirome hydrogen sulfate (5.09 g, yield 99.0%, purity ≥99.9%) was finally obtained. | | References | [1] Patent: CN105646542, 2016, A. Location in patent: Paragraph 0027; 0040; 0041; 0042; 0043; 0044; 0045 |
| | Cefpirome sulfate Preparation Products And Raw materials |
|