- N3-PEG5-CH2COOtBu
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2026-07-24
- CAS:1448451-72-6
- Min. Order: 1g
- Purity: 98%
- Supply Ability: 1g/bottle, 10g/bottle, 100g/bottle
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| | Azido-PEG5-CH2CO2t-butyl ester Basic information |
| Product Name: | Azido-PEG5-CH2CO2t-butyl ester | | Synonyms: | Reaxys ID: 23811246;Azido-PEG5-CH2CO2t-butyl ester;AZIDO-PEG5-CH2CO2TBU;N3-PEG5-CH2COOtBu;Azido-PEG5-Boc;Azido-PEG5-CH2COOtBu;Azido-PEG5-CH2COOH t-Bu Ester;N3-PEG5-CH2COOtBu/3,6,9,12,15-Pentaoxaheptadecanoic acid, 17-azido-, 1,1-dimethylethyl ester | | CAS: | 1448451-72-6 | | MF: | C16H31N3O7 | | MW: | 377.44 | | EINECS: | | | Product Categories: | peg | | Mol File: | 1448451-72-6.mol |  |
| | Azido-PEG5-CH2CO2t-butyl ester Chemical Properties |
| storage temp. | Store at 0-8 °C |
| | Azido-PEG5-CH2CO2t-butyl ester Usage And Synthesis |
| Description | Azido-PEG5-CH2CO2-t-Bu consist of an azide group(N3) and a t-butyl ester.The azide group can react with alkyne, BCN, DBCO via Click Chemistry. The t-butyl protected carboxyl group can be deprotected under acidic conditions. PEG spacer increases solubility in aqueous media. | | Uses | Azido-PEG5-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG5-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Azido-PEG5-CH2CO2t-butyl ester Preparation Products And Raw materials |
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