N3-PEG3-tBu

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N3-PEG3-tBu manufacturers

  • N3-PEG3-tBu
  • N3-PEG3-tBu pictures
  • 2026-07-16
  • CAS:252881-73-5
  • Min. Order: 1KG
  • Purity: 98%
  • Supply Ability: 1000kgs
N3-PEG3-tBu Basic information
Product Name:N3-PEG3-tBu
Synonyms:N3-PEG3-CH2CH2COOtBu;N3-PEG3-tBu;N3-PEG3-CH2CH2COOtBu;3-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]propanoic acid 1,1-dimethylethyl ester;tert-butyl 3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)propanoate;Azido-PEG3-COOtBu;tert-Butyl 3-(2-(2-(2-azidoethoxyl)ethoxy)ethoxy)propanoate;N3-?PEG3-?t-?butyl ester
CAS:252881-73-5
MF:C13H25N3O5
MW:303.3547
EINECS:
Product Categories:SiChem;peg
Mol File:252881-73-5.mol
N3-PEG3-tBu Structure
N3-PEG3-tBu Chemical Properties
storage temp. Storage temp. 2-8°C
form Liquid
color Colorless to light yellow
Safety Information
MSDS Information
N3-PEG3-tBu Usage And Synthesis
DescriptionAzido-PEG3-t-butyl ester is a click chemistry reagent. The hydrophilic PEG spacer increases solubility in aqueous media. The azide (N3) group canis reactive with alkyne, such as BCN, DBCO via Click Chemistry. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
UsesAzido-PEG3-t-butyl Ester is used as a linker in the conjugation of peptides.
Biological ActivityN3-PEG3-tBu is a cleavable ADC linker containing 3-unit PEG, which can be used to synthesize antibody drug conjugates (ADC). It is also a PROTAC linker, belonging to the PEG and Alkyl/ether classes, which can be used to synthesize PROTAC molecules.
in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

target

PEGs

Alkyl/ether

Cleavable

N3-PEG3-tBu Preparation Products And Raw materials
Preparation Productstert-Butyl 12-amino-4 7 10-trioxa-dodeca
Tag:N3-PEG3-tBu(252881-73-5) Related Product Information
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