- 2'-O-Methylcytidine
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2026-09-07
- CAS:2140-72-9
- Min. Order: 1kg
- Purity: 99%MIN
- Supply Ability: 20tons
- 2'-O-Methylcytidine
-
-
2024-08-07
- CAS:2140-72-9
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 300KG per month
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| | 2'-O-Methylcytidine Basic information |
| Product Name: | 2'-O-Methylcytidine | | Synonyms: | 4-amino-1-[(2R,3R,4R,5R)-4-hydroxy-3-methoxy-5-methylol-tetrahydrofuran-2-yl]pyrimidin-2-one;4-amino-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]pyrimidin-2-one;4-azanyl-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxy-oxolan-2-yl]pyrimidin-2-one;2'-OMe Cytidine;4-aMino-1-[(2R,3R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)-3-Methoxyoxolan-2-yl]-1,2-dihydropyriMidin-2-one;2'-O-Methylcytidine, >98.0%(HPLC);2'-O-Methylcytidine, >=99%;2''-(O-METHYL)-CYTIDINE, HPLC PURIFIED, 98% PURE WITH HPLC UV CHROMATOGRAM | | CAS: | 2140-72-9 | | MF: | C10H15N3O5 | | MW: | 257.24 | | EINECS: | 2017-001-1 | | Product Categories: | Bases & Related Reagents;Carbohydrates & Derivatives;Heterocycles;Nucleotides;Nucleosides, Nucleotides, Oligonucleotides;Biochemicals and Reagents;Nucleoside Analogs;Nucleosides;Modified（deoxy）nucleoside;Nucleosides-2'-OMe Nucleosides | | Mol File: | 2140-72-9.mol |  |
| | 2'-O-Methylcytidine Chemical Properties |
| Melting point | 252-253 C | | Boiling point | 506.0±60.0 °C(Predicted) | | density | 1.68±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C | | solubility | Soluble in DMSO. | | pka | 13.37±0.70(Predicted) | | form | Powder | | color | White to Off-white | | PH | 4.2 | | Optical Rotation | 70.902° (C=0.01 g/ml, H2O) | | λmax | 281 (pH 1)；273 (EtOH) | | Major Application | pharmaceutical | | InChI | InChI=1S/C10H15N3O5/c1-17-8-7(15)5(4-14)18-9(8)13-3-2-6(11)12-10(13)16/h2-3,5,7-9,14-15H,4H2,1H3,(H2,11,12,16)/t5-,7-,8-,9-/m1/s1 | | InChIKey | RFCQJGFZUQFYRF-ZOQUXTDFSA-N | | SMILES | OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)[C@H](OC)[C@@H]1O | | CAS DataBase Reference | 2140-72-9(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-24/25 | | WGK Germany | 3 | | HS Code | 29349990 | | Storage Class | 11 - Combustible Solids |
| | 2'-O-Methylcytidine Usage And Synthesis |
| Description | 2'-O-Methylcytidine is a nucleoside with a hydroxyl group on the 2' carbon, making it an effective viral replication inhibitor. 2'-O-Methylcytidine is also metabolized by nucleotide salvage pathways and may be able to bind to the response element on DNA, which could inhibit protein synthesis in cancer cells. It is an inhibitor of hepatitis C virus (HCV) non-structural protein 5B (NS5B; IC50 = 3.8 μM). It inhibits HCV replication in a replicon assay (IC50 = 21.2 μM). | | Chemical Properties | White powder | | Uses | 2'-O-Methylcytidine is used in the preparation of nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase. | | Uses | Cytidine analog. | | Definition | ChEBI: 2'-O-methylcytidine is a methylcytidine. | | References | [1] GIOVANNI MIGLIACCIO. Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro.[J]. The Journal of Biological Chemistry, 2003, 278 49: 49164-49170. DOI: 10.1074/jbc.m305041200 |
| | 2'-O-Methylcytidine Preparation Products And Raw materials |
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