| Company Name: |
TargetMol |
| Tel: |
400-821-0310 15002144251 |
| Email: |
xuexiang.shao@tsbiochem.com |
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| | 9,11-DIOXO-15S-HYDROXY-PROST-13E-EN-1-OIC ACID Basic information |
| | 9,11-DIOXO-15S-HYDROXY-PROST-13E-EN-1-OIC ACID Chemical Properties |
| Boiling point | 551.8±50.0 °C(Predicted) | | density | 1.127±0.06 g/cm3(Predicted) | | solubility | DMF: >100 mg/ml (from PGD2); DMSO: >50 mg/ml (from PGD2); Ethanol: >75 mg/ml (from PGD2); PBS pH 7.2: >2.7 mg/ml (from 15-deoxy-d12, | | pka | 4.77±0.10(Predicted) |
| | 9,11-DIOXO-15S-HYDROXY-PROST-13E-EN-1-OIC ACID Usage And Synthesis |
| Description | Prostaglandin K1 (PGK1) is a 9,11-diketo analog of PGE1 or PGD1 . It is a PGE2 receptor subtype EP1 agonist that has 387-fold reduced potency compared to PGE2 .1 | | Uses | Prostaglandin K1 (compound 46) is a structurally modified analog of prostacyclin (prostanoid) with an EC50 of 2800 nM for EP1 and a Ki of 2800 nM[1]. | | Definition | ChEBI: PGK1 is a prostanoid. | | References | 1. Ungrin, M.D., Carrière, M.C., Denis, D., et al. Key structural features of prostaglandin E2 and prostanoid analogs involved in binding and activation of the human EP1 prostanoid receptor Mol. Pharmacol. 59(6),1446-1456(2001). |
| | 9,11-DIOXO-15S-HYDROXY-PROST-13E-EN-1-OIC ACID Preparation Products And Raw materials |
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