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β-Ht 933 dihydrochloride manufacturers
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| | β-Ht 933 dihydrochloride Basic information |
| Product Name: | β-Ht 933 dihydrochloride | | Synonyms: | 2-amino-6-ethyl-4,5,7,8-tetrahydro-6h-oxazolo(5,4-d)azepinedihydrochloride;5,6,7,8-tetrahydro-6-ethyl-4h-oxazolo(4,5-d)azepin-2-aminedihydrochloride;5-d)azepin-2-amine,5,6,7,8-tetrahydro-6-ethyl-4h-oxazolo(dihydrochloride;b-ht933;B-HT 933 DIHYDROCHLORIDE SELECTIVE A2 AD RENORE;Azepexole dihydrochloride, 6-Ethyl-5,6,7,8-tetrahydro-4H-oxazolo[4,5-d]azepin-2-amine dihydrochloride;Azepexole hydrochloride;Nsc310831 | | CAS: | 36067-72-8 | | MF: | C9H16ClN3O | | MW: | 217.7 | | EINECS: | | | Product Categories: | | | Mol File: | 36067-72-8.mol |  |
| | β-Ht 933 dihydrochloride Chemical Properties |
| storage temp. | Desiccate at RT | | solubility | H2O: >20 mg/mL | | form | solid | | color | white to off-white |
| WGK Germany | 2 | | RTECS | RQ5831345 |
| | β-Ht 933 dihydrochloride Usage And Synthesis |
| Description | B-HT 933 is an agonist of α2-adrenergic receptors (α2-ARs) with an EC50 value of 0.65 μM for contraction of canine sapheneous veins. It induces concentration-dependent inhibition of the twitch response in rat vas deferens and guinea pig ileum. B-HT 933 induces sedation and reduces motor activity in mice, an effect that is reversed by the α2-AR antagonist yohimbine . B-HT 933 decreases blood pressure and cardiac output in cats injected with 30 μg/kg intracisternally. It also exhibits antinociceptive effects in mice with ED50 values of 12.5, 20.5, and 6.1 mg/kg for the tail-immersion, tail-pinch, and acetic acid writhing tests, respectively. | | Uses | B-HT 933 Dihydrochloride is a selective α2-adrenoceptor agonist and has less potent inhibitory effect on the sympathetic vasopressor responses in diabetic rats. | | in vitro | b-ht 933, a selective α2-adrenoceptor agonist, contracts human subcutaneous resistance arteries by a mechanism largely dependent on the influx of extracellular ca2+, probably through voltage-operated calcium channels. this action involves a pertussis toxin-sensitive g protein, possibly gq [1]. | | in vivo | the dose-related effects of the selective α2-adrenoceptor agonist b-ht 933 on the body temperature of untreated and reserpine-treated mice were investigated. in untreated mice b-ht 933 induced a dose-related hypothermia. the highest dose of b-ht 933 elicited a marked hypothermia, whereas the maximal hypothermic effect of clonidine was less pronounced and reached a plateau at a dose of 0.5 mg/kg [2]. | | IC 50 | 0.44 μm | | storage | Desiccate at RT | | references | [1] n. a. parkinson & a.d. hughes. the mechanism of action of 1c2-adrenoceptors in human isolated subcutaneous resistance arteries. british journal of pharmacology (1995) 115, 1463-1468
[2] d. j. bill, i.e. hughes & r.j. stephens. the thermogenic actions of x2-adrenoceptor agonists in reserpinized mice are mediated via a central postsynaptic ac2-adrenoceptor mechanism. br. j. pharmacol. (1989), 96, 133-143 |
| | β-Ht 933 dihydrochloride Preparation Products And Raw materials |
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