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| | 3-(Dimethylamino)-1-(pyridine-2-yl)prop-2-en-1-one Basic information | | Synthesis |
| Product Name: | 3-(Dimethylamino)-1-(pyridine-2-yl)prop-2-en-1-one | | Synonyms: | 3-(Dimethylamino)-1-(pyridin-2-yl)prop-2-en-1-one 98%;JR-8942, 3-(Dimethylamino)-1-(2-pyridyl)-2-propen-1-one, 97%;3-(DIMETHYLAMINO)-1-(2-PYRIDYL)-2-PROPE&;(E)-3-DiMethylaMino-1-(2-pyridyl)-2-propen-1-one, 98%;2-[3-(Dimethylamino)acryloyl]pyridine;3-(Dimethylamino)-1-(pyridin-2-yl)prop-2-en-1-one;(E)-3-dimethylamino-1-(2-pyridyl)prop-2-en-1-one;3-(Dimethylamino)-1-(2-pyridyl)-2-propen-1-one 95% | | CAS: | 66521-54-8 | | MF: | C10H12N2O | | MW: | 176.22 | | EINECS: | | | Product Categories: | C9 to C46;Heterocyclic Building Blocks;Pyridines | | Mol File: | 66521-54-8.mol |  |
| | 3-(Dimethylamino)-1-(pyridine-2-yl)prop-2-en-1-one Chemical Properties |
| Melting point | 126-130 °C(lit.) | | Boiling point | 281.4±36.0 °C(Predicted) | | density | 1.07 | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 6.25±0.70(Predicted) | | Appearance | Yellow to brown Solid | | InChI | 1S/C10H12N2O/c1-12(2)8-6-10(13)9-5-3-4-7-11-9/h3-8H,1-2H3/b8-6+ | | InChIKey | BWERGHWJEBQNQV-SOFGYWHQSA-N | | SMILES | CN(C)\C=C\C(=O)c1ccccn1 |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | HS Code | 2933399990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 3-(Dimethylamino)-1-(pyridine-2-yl)prop-2-en-1-one Usage And Synthesis |
| Synthesis | 3-(Dimethylamino)-1-(pyridine-2-yl)prop-2-en-1-one was synthesised based on the literature. The reaction of (2g, 16.5mmol) of 2-acetylpyridine and DMF dimethyl acetal(7.84g) were suspended in 11ml of xylene and stir this reaction mixture for 16h at 110℃. Into the resulting mixture 10 ml of hexane added yellow colour precipitate was formed and allows stirring for 20min at 3℃. Resulting mixture was filtered and dried in vacuum to get a yellow colour powder. | | Uses | 3-(Dimethylamino)-1-(2-pyridyl)-2-propen-1-one may be used in the preparation of the 5-(heteroaryl)isoxazole derivatives, 5-(2-pyridyl)isoxazole and 3-methyl-5-(2-pyridyl)isoxazole. It may also be used to synthesize 7-(2-pyridyl)-1,2,4-triazolo[1,5-a]pyrimidine. | | General Description | 3-(Dimethylamino)-1-(2-pyridyl)-2-propen-1-one (1-(2′-Pyridyl)-3-dimethylamino-2-propen-1-one), an enaminone, is a hemilabile hybrid ligand. The preparation of cationic mononuclear rhodium(I) or iridium(I) complexes containing 3-(dimethylamino)-1-(2-pyridyl)-2-propen-1-one have been reported. | | References | [1] Molecules, 2007, vol. 12, # 8, p. 2061 - 2079
[2] European Journal of Organic Chemistry, 2012, # 32, p. 6407 - 6413,7
[3] Synthetic Communications, 1993, vol. 23, # 13, p. 1897 - 1903
[4] Organic Preparations and Procedures International, 1997, vol. 29, # 3, p. 285 - 292
[5] Journal of Chemical Research, Miniprint, 1997, # 3, p. 601 - 615 |
| | 3-(Dimethylamino)-1-(pyridine-2-yl)prop-2-en-1-one Preparation Products And Raw materials |
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