5-FLUORO-1,3-DIHYDRO-BENZIMIDAZOL-2-ONE manufacturers
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| | 5-FLUORO-1,3-DIHYDRO-BENZIMIDAZOL-2-ONE Basic information |
| Product Name: | 5-FLUORO-1,3-DIHYDRO-BENZIMIDAZOL-2-ONE | | Synonyms: | 5-FLUORO-1,3-DIHYDROBENZOIMIDAZOL-2-ONE, 95+%;5-Fluoro-1,3-dihydrobenzoimidazol-2-one;5-fluoro-1,3-dihydro-2H-benzimidazol-2-one;2H-BenziMidazol-2-one, 5-fluoro-1,3-dihydro-;5-Fluoro-1H-benzo[d]iMidazol-2(3H)-one;5-Fluoro-1H-benzo[d]imidazol-2(3H);5-FLUOROBENZIMIDAZOLONE;5-FLUORO-1,3-DIHYDRO-BENZIMIDAZOL-2-ONE | | CAS: | 1544-75-8 | | MF: | C7H5FN2O | | MW: | 152.13 | | EINECS: | 200-258-5 | | Product Categories: | BENZIMIDAZOLE | | Mol File: | 1544-75-8.mol |  |
| | 5-FLUORO-1,3-DIHYDRO-BENZIMIDAZOL-2-ONE Chemical Properties |
| Melting point | 300 °C | | Boiling point | 118.8±19.0 °C(Predicted) | | density | 1.366±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 11.00±0.30(Predicted) | | Appearance | White to off-white Solid |
| | 5-FLUORO-1,3-DIHYDRO-BENZIMIDAZOL-2-ONE Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 5-fluoro-1H-benzo[d]imidazol-2(3H)-ones from carbon dioxide and 4-fluoro-1,2-benzenediamine was as follows: 4-fluoro-1,2-benzenediamine (1 mmol), Catalyst I (0.15 mmol), and N-methylpyrrolidone (NMP, 1 mL) were added in a Schlenk tube and placed in a magnetic stirrer. Carbon dioxide (1 atm) was passed into the reaction system via a balloon and the reaction mixture was subsequently stirred at 140 °C for 24 hours. The reaction progress was monitored periodically by GC, LC, GC-MS or NMR. For the reaction under high pressure conditions, the reaction was carried out by placing the reactants in a Teflon vessel and then in a stainless steel autoclave and passing carbon dioxide up to 20 atm. | | References | [1] Angewandte Chemie - International Edition, 2012, vol. 51, # 27, p. 6700 - 6703
[2] Chemistry - An Asian Journal, 2016, vol. 11, # 19, p. 2735 - 2740
[3] ACS Catalysis, 2013, vol. 3, # 9, p. 2076 - 2082
[4] Catalysis Today, 2014, vol. 226, p. 160 - 166 |
| | 5-FLUORO-1,3-DIHYDRO-BENZIMIDAZOL-2-ONE Preparation Products And Raw materials |
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