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- 2-Iodobenzonitrile
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2025-04-04
- CAS:4387-36-4
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 500kg
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| | 2-Iodobenzonitrile Basic information |
| | 2-Iodobenzonitrile Chemical Properties |
| Melting point | 52-54°C | | Boiling point | 147 °C / 15mmHg | | density | 1.91±0.1 g/cm3(Predicted) | | Fp | 110 °C | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | soluble in Methanol | | form | Solid | | color | Yellow | | InChI | InChI=1S/C7H4IN/c8-7-4-2-1-3-6(7)5-9/h1-4H | | InChIKey | JDDAFHUEOVUDFJ-UHFFFAOYSA-N | | SMILES | C(#N)C1=CC=CC=C1I | | CAS DataBase Reference | 4387-36-4(CAS DataBase Reference) |
| Hazard Codes | Xi,Xn | | Risk Statements | 20/21/22-36/37/38-36-22 | | Safety Statements | 26-36/37/39 | | RIDADR | 3439 | | WGK Germany | 3 | | Hazard Note | Harmful | | HazardClass | IRRITANT-HARMFUL | | PackingGroup | III | | HS Code | 29269090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2 |
| | 2-Iodobenzonitrile Usage And Synthesis |
| Chemical Properties | Yellow solid | | Uses | suzuki reaction | | Uses | 2-Iodobenzonitrile is a nitrile compound. Nitrile compounds are one of the most important organic synthesis intermediates in organic synthetic chemistry and are widely used in pesticides, pharmaceuticals, dyes and other fine chemicals. Moreover, because o-iodobenzonitrile compounds contain both cyano and aryl carbon-iodide bonds, and both of them are in the adjacent position of benzene ring, 2-iodobenzonitrile can have excellent reactivity when used as intermediates. | | Synthesis | GENERAL STEPS: A THF solution (2 mL) of 2-iodobenzamide (1.0 mmol) and triethoxysilane (0.50 g, 3.0 mmol) was added to a 25 mL Schlenk tube. The reaction mixture was stirred continuously at 60 °C until complete consumption of 2-iodobenzamide was confirmed by thin layer chromatography (TLC) and gas chromatography-mass spectrometry (GC-MS). Upon completion of the reaction, 2-iodocyanobenzene was purified according to the method reported by Beller literature. | | References | [1] Tetrahedron Letters, 1986, vol. 27, # 20, p. 2203 - 2206
[2] Catalysis Communications, 2019, p. 72 - 75
[3] Catalysis Communications, 2016, vol. 86, p. 148 - 150
[4] Dalton Transactions, 2018, vol. 47, # 12, p. 4352 - 4359
[5] Journal of Organic Chemistry, 1965, vol. 30, p. 617 - 620 |
| | 2-Iodobenzonitrile Preparation Products And Raw materials |
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