DC-CHOL manufacturers
- DC-Chol hydrochloride
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- $30.00 / 10mg
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2026-03-05
- CAS:166023-21-8
- Min. Order:
- Purity: 98.00%
- Supply Ability: 10g
- DC-Chol
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- $0.00 / 1g
-
2026-02-05
- CAS:
- Min. Order: 1g
- Purity: 98%
- Supply Ability: 1g/bottle , 10g/bottle, 100g/bottle
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| | DC-CHOL Basic information |
| Product Name: | DC-CHOL | | Synonyms: | cholesteryl 3B-(N-(dimethylaminoethyl)*carbamate);3β-[n-(dimethylaminoethane) carbamoyl] cholesterol;CHOLESTERYL N-[DIMETHYL-AMINOETHYL]CARBAMATE HYDROCHLORIDE;DC-CHOL;DC-CHOLESTEROL;DC-Chol (hydrochloride);DC-CHO;DC-Cholesterol.HCl | | CAS: | 166023-21-8 | | MF: | C32H56N2O2.ClH | | MW: | 537.26 | | EINECS: | | | Product Categories: | | | Mol File: | 166023-21-8.mol |  |
| | DC-CHOL Chemical Properties |
| storage temp. | -20°C | | solubility | DMSO: > 5mg/mL; Methanol: > 10 mg/mL | | form | A crystalline solid | | color | White to light yellow | | InChIKey | ISXSJGHXHUZXNF-JSYXOEMKNA-N | | SMILES | C[C@]12CC[C@@H](CC1=CC[C@@]1([H])[C@]3([H])CC[C@@]([H])([C@]3(CC[C@@]12[H])C)[C@H](C)CCCC(C)C)OC(=O)NCCN(C)C.Cl |&1:1,4,9,11,15,17,20,23,r| |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | DC-CHOL Usage And Synthesis |
| Description | DC-Chol is a cationic cholesterol derivative. DC-Chol, as a component of lipoplexes with DOPE , has been used for transfection of mRNA into A549 cells without affecting cell viability. Incubation of DC-chol/DOPE liposomes or lipoplexes with human whole blood has no effect on neutrophil elastase or β-thromboglobulin levels or the number of platelets and red and white blood cells, indicating hemocompatibility. DC-Chol has also been widely used in the synthesis of liposomes for the delivery of siRNA, DNA, and chemotherapeutic agents into cells and mice. | | Uses | This cationic cholesterol derivative forms liposomes with L-α-phosphatidylethanolamine, dioleoyl, that efficiently transfect mammalian cell lines. | | Uses | DC-Cholesterol HCl is suitable:
- for the preparation of ultrasound cationic microbubbles
- to prepare liposomes
- for the preparation of L-glutathione (GSH), loaded proliposomes
| | General Description | DC-Cholesterol HCl is a sterol-based transfection reagent. | | Biochem/physiol Actions | DC-Cholesterol is an effective transfection agent and a liposome reagent. Liposome of DC-Cholesterol with dioleoylphosphatidylethanolamine (DOPE) are efficient for DNA transfection. It imparts positive surface charge to the microbubbles for ultra sound based transfection of clustered regularly interspaced short palindromic repeats (CRISPRs). | | storage | Store at -20°C | | References | [1] TATJANA MICHEL. Cationic Nanoliposomes Meet mRNA: Efficient Delivery of Modified mRNA Using Hemocompatible and Stable Vectors for Therapeutic Applications.[J]. Molecular Therapy. Nucleic Acids, 2017, 8: 459-468. DOI: 10.1016/j.omtn.2017.07.013
[2] JIE GAO . Lyophilized HER2-specific PEGylated immunoliposomes for active siRNA gene silencing[J]. Biomaterials, 2010, 31 9: Pages 2655-2664. DOI: 10.1016/j.biomaterials.2009.11.112
[3] RAN ZHANG. Codelivery of paclitaxel and small interfering RNA by octadecyl quaternized carboxymethyl chitosan-modified cationic liposome for combined cancer therapy.[J]. Journal of Biomaterials Applications, 2015, 30 3: 351-360. DOI: 10.1177/0885328215579297
[4] YING MEN. The efficacy of mitochondrial targeting antiresistant epirubicin liposomes in treating resistant leukemia in animals.[J]. International Journal of Nanomedicine, 2011: 3125-3137. DOI: 10.2147/ijn.s24847
[5] X XING. Safety studies of the intraperitoneal injection of E1A–liposome complex in mice[J]. Gene Therapy, 1997, 4 3: 238-243. DOI: 10.1038/sj.gt.3300376 |
| | DC-CHOL Preparation Products And Raw materials |
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