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| | 2-(2-Aminoethyl)isothiourea dihydrobromide Basic information | | ?Synthesis |
| Product Name: | 2-(2-Aminoethyl)isothiourea dihydrobromide | | Synonyms: | s-(beta-aminoethyl)isothiuroniumbromidehydrobromide;s-aminoethylisothiuroniumbromidehydrobromide;s-beta-aminoethylisothiuroniumbromohydrate;surrectan;usafxr-31;(2-aminoethyl)-2-thio-pseudouredihydrobromide;2-(2-aminoethyl)-2-thiopseudoureahydrobromide;2-(beta-aminoethyl)isothiouroniumbromidehydrobromide | | CAS: | 56-10-0 | | MF: | C3H11Br2N3S | | MW: | 281.01 | | EINECS: | 200-257-0 | | Product Categories: | | | Mol File: | 56-10-0.mol |  |
| | 2-(2-Aminoethyl)isothiourea dihydrobromide Chemical Properties |
| Hazard Codes | Xn | | Risk Statements | 22-36/37/38 | | Safety Statements | 26-36/37-22 | | WGK Germany | 3 | | RTECS | UM0175000 | | F | 10-21 | | TSCA | TSCA listed | | HS Code | 2930 90 98 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 | | Toxicity | LD50 in mice (mg/kg): 100 i.v., 280 s.c., 480 i.p., 1600 orally (Pospisil) |
| | 2-(2-Aminoethyl)isothiourea dihydrobromide Usage And Synthesis |
| ?Synthesis | Ethylamine thiourea is synthesized by using cycloethylamine, hydrobromic acid and thiourea as raw materials: firstly, thiourea is mixed with hydrogen bromide acid, and cycloethylamine is added dropwise at a temperature below 150 °C. After the reaction is completed, add activated carbon to filter, and then reduce Dehydration under pressure, crystals are precipitated when the temperature is below 50°C, filtered, and washed twice with absolute ethanol. | | Description | S-(2-aminoethyl) Isothiourea is a non-selective inhibitor of all NOS isoforms. For human nNOS, eNOS, and iNOS, the Ki values are 1.8, 2.1, and 0.59 μM, respectively. | | Chemical Properties | Crystals, hygroscopic. | | Uses | 2-(2-Aminoethyl)isothiourea dihydrobromide inhibits nitric oxide synthase (NOS). | | Uses | NOS inhibitor | | Uses | Has radioprotective activity against x-rays. | | in vivo | AE-ITU dihydrobromide (1 mg/kg/h, i.v., for 1 hour) attenuates the delayed hypotension and vascular hyporeactivity, ameliorates liver dysfunction in LPS (HY-D1056)-administrated Wistar rats[1]. | Animal Model: | LPS (HY-D1056)-administrated Wistar rats[1] | | Dosage: | 1 mg/kg | | Administration: | i.v., 1 mg/kg/h for 1 hour | | Result: | Reduced the serum levels of bilirubin, serum nitrite, GOT, GPT and γGT caused by LPS, inhibited iNOS in lung and liver homogenates. |
| | IC 50 | iNOS | | Purification Methods | Crystallise the salt from absolute EtOH/ethyl acetate or MeOH. Store dry as it is hygroscopic in a humid atmosphere. It is a radioprotective agent. When refluxed in EtOH for 16hours or H2O for 30minutes, it decomposes to 2-amino-4(5H)-thiazoline hydrobromide which on recrystallisation from isoPrOH/EtOAc has m 175-176o [Doherty et al. J Am Chem Soc 79 5667 1957]. | | references | [1]. garvey ep, oplinger ja, tanoury gj, et al. potent and selective inhibition of human nitric oxide synthases. inhibition by non-amino acid isothioureas. j biol chem. 1994 oct 28;269(43):26669-76. |
| | 2-(2-Aminoethyl)isothiourea dihydrobromide Preparation Products And Raw materials |
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