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| | Ethyl (ethoxymethylene)cyanoacetate Basic information |
| | Ethyl (ethoxymethylene)cyanoacetate Chemical Properties |
| Hazard Codes | Xi,T,Xn | | Risk Statements | 36/37/38-42/43-41-37/38-22 | | Safety Statements | 26-37/39 | | RIDADR | 3276 | | WGK Germany | 1 | | Hazard Note | Toxic | | TSCA | TSCA listed | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 29269090 | | Storage Class | 11 - Combustible Solids |
| | Ethyl (ethoxymethylene)cyanoacetate Usage And Synthesis |
| Chemical Properties | white to light yellow crystalline solid | | Uses | Ethyl Cyano(ethoxymethylene)acetate is an intermediate in the synthesis of anti-inflammatory agents with gastroprotective effect in rats. | | Synthesis | a) General procedure for the preparation of ethyl 4-(2-cyano-2-ethoxycarbonylvinylamino)benzoate: triethyl orthoformate (33.3 mL, 0.2 mol) was mixed with ethyl cyanoacetate (21.3 mL, 0.2 mol) in acetic acid anhydride (80 mL), and the mixture was heated for 5 hr at 150-160 °C. Upon completion of the reaction, it was cooled to room temperature and the solvent was removed by distillation under reduced pressure to give ethyl 2-cyano-3-ethoxyacrylate as a yellow solid (28.5 g, 84% yield). | | References | [1] Patent: US2006/4046, 2006, A1. Location in patent: Page/Page column 35
[2] Patent: WO2014/145986, 2014, A1. Location in patent: Paragraph 0274
[3] Arkivoc, 2017, vol. 2017, # 3, p. 73 - 86
[4] Phosphorus, Sulfur and Silicon and the Related Elements, 2006, vol. 181, # 3, p. 591 - 599
[5] Patent: US2012/277224, 2012, A1. Location in patent: Page/Page column 18 |
| | Ethyl (ethoxymethylene)cyanoacetate Preparation Products And Raw materials |
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