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Manzamine a manufacturers
- Manzamine A
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- $575.00
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2026-07-30
- CAS:104196-68-1
- Purity:
- Supply Ability: 10g
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| | Manzamine a Basic information |
| Product Name: | Manzamine a | | Synonyms: | 1,13-Etheno-4,21a-methano-1H-azocino[1',2':1,5]pyrrolo[3,2-e]azacyclopentadecin-13(13aH)-ol, 2,3,5,6,7,8,11,12,15,16,17,18,20a,21-tetradecahydro-24-(9H-pyrido[3,4-b]indol-1-yl)-, (1R,4S,9Z,13S,13aR,20aR,21aR)-;Keramamine A;Manzamine a | | CAS: | 104196-68-1 | | MF: | C36H44N4O | | MW: | 548.76 | | EINECS: | | | Product Categories: | | | Mol File: | 104196-68-1.mol |  |
| | Manzamine a Chemical Properties |
| Melting point | >240(disassembly) | | Boiling point | 756.6±60.0 °C(Predicted) | | density | 1.26±0.1 g/cm3(Predicted) | | storage temp. | -20° | | solubility | Soluble in DMSO (up to 25 mg/ml). | | form | Off white to yellow solid. | | pka | 13.58±0.40(Predicted) | | color | Off-White to Pale Yellow | | Optical Rotation | +5020 (CHCl3) | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| | Manzamine a Usage And Synthesis |
| Description | Manzamine A (104196-68-1) inhibits vacuolar ATPases and inhibits autophagy in pancreatic cancer cells1. Suppresses atherosclerosisin vivo2. Manzamine A displays neuritogenic activity3and suppresses tau hyperphosphorylation in human neuroblastoma cell lines4. | | Uses | Manzamine A is a β-Carboline alkaloid with anti-inflammatory. | | Definition | ChEBI: An alkaloid of the class of beta-carbolines isolated from Haliclona and Acanthostrongylophora. It exhibits inhibitory activity against Glycogen Synthase Kinase-3 (EC 2.7.11.26). | | in vivo | Manzamine A (50 and 100 mol/kg, p.o. or i.p.) inhibits the growth of the rodent malaria parasitePlasmodium berghei in infected mice[6].
Manzamine A (8 mg/kg, i.p., daily for 8 consecutive days) prolongs the survival of SW mice to 20 days[7].
| Animal Model: | Plasmodium berghei in infected mice[6] | | Dosage: | 50 or 100 mol/kg | | Administration: | Intraperitoneal injection (i.p.) or oral administration (p.o.) | | Result: | Inhibited the growth of the rodent malaria parasite Plasmodium berghei.
Prolonged the survival of highly parasitaemic mice.
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| | IC 50 | Plasmodium; GSK-3β: 10.2 μM (IC50); CDK5: 1.5 μM (IC50); vacuolar ATPases; Malaria; HSV-1 | | storage | +4°C | | References | [1] GEORGIOS KALLIFATIDIS. The marine natural product manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells.[J]. Marine Drugs, 2013, 11 9: 3500-3516. DOI:10.3390/md11093500
[2] KEISUKE EGUCHI . Manzamine A, a marine-derived alkaloid, inhibits accumulation of cholesterol ester in macrophages and suppresses hyperlipidemia and atherosclerosis in vivo[J]. Bioorganic & Medicinal Chemistry, 2013, 21 13: Pages 3831-3838. DOI:10.1016/j.bmc.2013.04.025
[3] BO ZHANG. Neuritogenic activity-guided isolation of a free base form manzamine A from a marine sponge, Acanthostrongylophora aff. ingens (Thiele, 1899).[J]. Chemical & pharmaceutical bulletin, 2008, 56 6: 866-869. DOI:10.1248/cpb.56.866
[4] MARK HAMANN. Glycogen Synthase Kinase-3 (GSK-3) Inhibitory Activity and Structure–Activity Relationship (SAR) Studies of the Manzamine Alkaloids. Potential for Alzheimer’s Disease[J]. Journal of Natural Products , 2007, 70 9: 1397-1405. DOI:10.1021/np060092r |
| | Manzamine a Preparation Products And Raw materials |
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