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7-Bromo-4-chloroquinazoline

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7-Bromo-4-chloroquinazoline manufacturers
7-Bromo-4-chloroquinazoline Basic information
Product Name:7-Bromo-4-chloroquinazoline
Synonyms:7-Bromo-4-chloro-quizoline;7-BroMo-4-chloroquinazoli...;Quinazoline, 7-bromo-4-chloro-;7-Bromo-4-chloroquinazoline
CAS:573675-55-5
MF:C8H4BrClN2
MW:243.49
EINECS:
Product Categories:Halides;CHIRAL CHEMICALS;Fused Ring Systems
Mol File:573675-55-5.mol
7-Bromo-4-chloroquinazoline Structure
7-Bromo-4-chloroquinazoline Chemical Properties
Boiling point 339.7±22.0 °C(Predicted)
density 1.762±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka0.09±0.30(Predicted)
AppearanceOff-white to light yellow Solid
Safety Information
Hazard Codes T
Risk Statements 41-25
Safety Statements 26-39-45
RIDADR UN2811
HS Code 2933599590
MSDS Information
7-Bromo-4-chloroquinazoline Usage And Synthesis
Synthesis
7-BROMO-1H-QUINAZOLIN-4-ONE

194851-16-6

7-BROMO-4-CHLOROQUINAZOLINE

573675-55-5

General procedure for the synthesis of 7-bromo-4-chloroquinazoline from 7-bromo-3,4-dihydroquinazolin-4-one: 20.4 mL (0.12 mol) of N-ethyl diisopropylamine was added slowly and dropwise to 55.0 g (0.24 mol) of 7-bromo-3H-quinazolin-4-one suspended in 300 mL of phosphorus trichloride. The reaction mixture was stirred at 115 °C for 3 hours and subsequently cooled to room temperature. After conventional post-processing, 48.0 g of the target product 7-bromo-4-chloroquinazoline was obtained as a solid as confirmed by HPLC/MS analysis ([M+H]+ = 244).

References[1] Patent: US2013/12489, 2013, A1. Location in patent: Paragraph 0183
[2] Patent: WO2010/146173, 2010, A1. Location in patent: Page/Page column 16-17
[3] Patent: WO2005/42498, 2005, A2. Location in patent: Page/Page column 43
[4] Chemical Biology and Drug Design, 2018, vol. 92, # 5, p. 1859 - 1866
7-Bromo-4-chloroquinazoline Preparation Products And Raw materials
Raw materials7-Bromo-1H-quinazolin-4-one
Tag:7-Bromo-4-chloroquinazoline(573675-55-5) Related Product Information
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