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| | S-Methyl-L-thiocitrulline dihydrochloride Basic information |
| Product Name: | S-Methyl-L-thiocitrulline dihydrochloride | | Synonyms: | S-MTC dihydrochloride;JNZHDSKJUXGYRG-XRIGFGBMSA-N;(S,E)-2-Amino-5-((amino(methylthio)methylene)amino)pentanoic acid dihydrochloride;L-Ornithine, N5-[imino(methylthio)methyl]-, hydrochloride (1:2) | | CAS: | 209589-59-3 | | MF: | C7H15N3O2S.2HCl | | MW: | 278.2 | | EINECS: | | | Product Categories: | | | Mol File: | 209589-59-3.mol |  |
| | S-Methyl-L-thiocitrulline dihydrochloride Chemical Properties |
| storage temp. | Freezer (-20°C) | | solubility | DMF: >14 mg/ml; DMSO: >20 mg/ml; Ethanol: >75 mg/ml; PBS pH 7.2: >25 mg/ml | | form | White to off-white solid. | | color | white to off-white | | Water Solubility | water: 50mg/mL | | InChI | 1S/C7H15N3O2S/c1-13-7(9)10-4-2-3-5(8)6(11)12/h5H,2-4,8H2,1H3,(H2,9,10)(H,11,12)/t5-/m0/s1 | | InChIKey | NGVMVBQRKZPFLB-YFKPBYRVSA-N | | SMILES | S(C)\C(=N/CCC[C@H]([N+H3])C(=O)[O-])\N |
| WGK Germany | WGK 3 | | HS Code | 29310099 | | Storage Class | 11 - Combustible Solids |
| | S-Methyl-L-thiocitrulline dihydrochloride Usage And Synthesis |
| Chemical Properties | white to tan amorphous powder | | Uses | S-Methyl-L thiocitrulline, Dihydrochloride is a potent inhibitor of NOS1 and NOS3. | | Definition | ChEBI: S-methyl-L-Thiocitrulline (hydrochloride) is a L-alpha-amino acid. | | Biological Activity | Cell permeable: yes', 'Primary Target
R at neuronal nitric oxide synthase', 'Product does not compete with ATP.', 'Reversible: no', 'Target IC50: 300 nM for r at neuronal nitric oxide synthase | | in vivo | S-MTC dihydrochloride (S-methyl-L-thiocitrulline) is a selective neuronal NOS-inhibitor. Following pretreatment with S-MTC dihydrochloride (i.c.v.), the HBO2-induced antinociception is significantly antagonized. In Experiment #2, different groups of mice are pretreated with naltrexone hydrochloride (NTX) (3.0 mg/kg, i.p.), L-NAME (1.0 μg/mouse, i.c.v.), S-MTC dihydrochloride (1.0 μg/mouse, i.c.v.) or N5-(1-iminoethyl)-L-ornithine (L-NIO) (3.0 mg/kg, s.c.) 15-30 min prior to HBO2 treatment. The antinociceptive effect assessed 90 min after HBO2 treatment is completely abolished by NTX and L-NAME, antagonized by two-thirds by S-MTC dihydrochloride and largely unaffected by L-NIO (F=25.57, p<0.0001)[2]. At a dose of 0.3 mg/kg, S-MTC dihydrochloride (SMTC) causes a rise in mean blood pressure (BP). At doses of 1.0, 3.0 and 10 mg/kg, S-MTC dihydrochloride causes falls in heart rate, rises in BP and vasoconstriction in all three vascular beds[3]. |
| | S-Methyl-L-thiocitrulline dihydrochloride Preparation Products And Raw materials |
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