- 4-Methylpyridin-2-amine
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- $0.00 / 1KG
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2026-03-06
- CAS:695-34-1
- Min. Order: 1KG
- Purity: 98%min
- Supply Ability: 30tons/month
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| | 4-Methylpyridin-2-amine Basic information |
| | 4-Methylpyridin-2-amine Chemical Properties |
| Melting point | 96-99 °C (lit.) | | Boiling point | 230 °C (lit.) | | density | 1.0275 (estimate) | | vapor pressure | 3.71Pa at 25℃ | | refractive index | 1.5560 (estimate) | | Fp | 118 °C | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | DMF: freely soluble | | pka | pK1: 7.48(+1) (25°C) | | form | Flakes | | color | Slightly yellow to beige or brown | | Water Solubility | SOLUBLE | | Sensitive | Hygroscopic | | Merck | 14,466 | | BRN | 107066 | | InChI | 1S/C6H8N2/c1-5-2-3-8-6(7)4-5/h2-4H,1H3,(H2,7,8) | | InChIKey | ORLGLBZRQYOWNA-UHFFFAOYSA-N | | SMILES | Cc1ccnc(N)c1 | | LogP | 0.56-1.08 | | CAS DataBase Reference | 695-34-1(CAS DataBase Reference) | | NIST Chemistry Reference | 2-Pyridinamine, 4-methyl-(695-34-1) | | EPA Substance Registry System | 2-Pyridinamine, 4-methyl- (695-34-1) |
| Hazard Codes | T | | Risk Statements | 45-46-60-61-8-21-25-26-34-42/43-48/23-50/53-36/37/38-33-23/24/25 | | Safety Statements | 53-45-60-61-37/39-28A-26-36/37/39 | | RIDADR | UN 3086 6.1/PG 1 | | WGK Germany | 3 | | RTECS | TJ5150000 | | TSCA | TSCA listed | | HazardClass | 6.1 | | PackingGroup | II | | HS Code | 29333999 | | Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | | Hazard Classifications | Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Aquatic Chronic 3
Eye Dam. 1
Skin Corr. 1B | | Toxicity | LD50 oral in rat: 200mg/kg |
| | 4-Methylpyridin-2-amine Usage And Synthesis |
| Chemical Properties | Light yellow to brown flakes | | Uses | Intermediate, medicine. | | Uses | 4-Methylpyridin-2-amine has been used in the synthesis of 2-amino-4-methyl-pyridinium 2-hy-droxy-benzoate. It is potent inhibitor of NOS2 (iNOS) in vitro. It is used as pharmaceutical intermediate. | | Synthesis Reference(s) | The Journal of Organic Chemistry, 72, p. 4554, 2007 DOI: 10.1021/jo070189y | | General Description | 4-Methylpyridin-2-amine acts as ligand and forms methoxo-bridged copper(II) complexes. | | Biochem/physiol Actions | 4-Methylpyridin-2-amine inhibits the activity of inducible NO synthase isolated from mouse RAW 264.7 cells in vitro. | | Synthesis |
A mixture of 2-amino-3-chloro-4-methylpyridine 0.96 g (0. 0067πο1) and benzoic acid, 1.83 g (0.015 mol) was added, the copper powder was added, reacted at 150 ° C for 1 h, and the reaction solution was added to water, Adding the decolorizer, adjusting the pH of the filtered solution to pH 9, filtering and drying the filter cake to obtain 0.65 g of crude 4-Methylpyridin-2-amine as a yellow solid, the yield was 89.3percent. The crude 0.65g dissolved in dilute hydrochloric acid solution to the crude product completely dissolved to obtain a salt solution, adding ethyl acetate to the salt solution to extract the water phase, slowly adding sodium bicarbonate to the aqueous phase Solution to pH 9, the solid was completely precipitated, filtered, and the filtrate was washed with distilled water and dried in vacuo to give 0.53 g of 4-Methylpyridin-2-amine as a pale yellow solid.
| | Purification Methods | Crystallise it from EtOH or a 2:1 *benzene/acetone mixture, and dry it under vacuum as in the prevous entry. [Beilstein 22/9 V 325.] | | References | [1] Patent: CN107011254, 2017, A. Location in patent: Paragraph 0022; 0042; 0043; 0046; 0047 |
| | 4-Methylpyridin-2-amine Preparation Products And Raw materials |
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