10β,17β-dihydroxyestra-1,4-dien-3-one NEW
| Price | $99 |
| Package | 2mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-17 |
Product Details
| Product Name: 10β,17β-dihydroxyestra-1,4-dien-3-one | CAS No.: 549-02-0 |
| Supply Ability: 10g | Release date: 2025/07/17 |
Product Introduction
Bioactivity
| Name | 10β,17β-dihydroxyestra-1,4-dien-3-one |
| Description | 10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) is a brain-selective prodrug of 17β-estradiol, which has neuroprotective effects, improves cognitive dysfunction, and can be used to study brain damage. |
| In vivo | The effect of 10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) on PR expression has also been evaluated on animals. PR expression in brains taken from morphine-treated rats manifested the same response to 10β,17β-dihydroxyestra-1,4-dien-3-one or EE as in OVX rats not treated with morphine. These animals were treated with the test compounds (10β,17β-dihydroxyestra-1,4-dien-3-one 30 and 100μg/kg, EE 200μg/kg, and vehicle) via oral gavage twice per day. As indicated by optical density on film exposures, that induction of the highly estrogen-responsive gene was three fold higher in the 10β,17β-dihydroxyestra-1,4-dien-3-one - and EE-treated groups than in the vehicle-treated animals. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (277.41 mM), Sonication is recommended. |
| Keywords | EstrogenReceptor | Estrogen Receptor/ERR | Estrogen Receptor | ERR | 10β,17β-dihydroxyestra-1,4-dien-3-one | 10β,17βdihydroxyestra1,4dien3one | 10β,17β dihydroxyestra 1,4 dien 3 one | 10beta,17beta-dihydroxyestra-1,4-dien-3-one | 10b,17b-dihydroxyestra-1,4-dien-3-one |
| Inhibitors Related | Kaempferol | Tamoxifen | Estradiol | Estradiol benzoate | ARV-471 | Octinoxate | Genistin | Cholesterol | Estriol | Chrysin | Ethisterone | Estrone |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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