HESPERETIN

(1) Antioxidant effect: hesperidin can eliminate peroxynitrite ion to avoid the harm of peroxidation.

(2) Anti inflammatory effect: hesperidin can inhibit the mediating effect of inflammatory mediators, thereby indirectly inhibiting the inflammatory reaction. Compared with hesperidin, hesperidin has stronger anti-inflammatory effect. Hesperidin C7 linked with rutose has an effect on its anti-inflammatory activity.

(3) Hypolipidemic effect: hesperidin can inhibit cholesterol producing enzyme and esterifying enzyme, so as to achieve the effect of Hypolipidemia.

(4) Cardiovascular protection: hesperidin has the effect of reducing blood lipid and vascular permeability, which can prevent thrombosis. Hesperidin can also protect the endothelial cells from hypoxia by stimulating some mitochondrial enzymes such as succinate dehydrogenase, and prevent thrombosis caused by endothelial necrosis. In addition, hesperidin can inhibit PLC by inhibiting the growth of PLC γ Phosphorylation of 2 and its downstream signal conduction promote the anticoagulant activity, prevent thrombosis and benefit cardiovascular system.

(5) Antitumor effect: hesperidin has antioxidant effect, thus avoiding the carcinogenesis caused by gene changes caused by these factors. Flavonoid (hesperidin, etc.) can change the permeability of BBB to vincristine, which is also related to its concentration. Low concentration of flavonoids can reduce the uptake of vincristine by brain capillary endothelial cells; On the contrary, high concentration has a promoting effect.