Clotrimazole

CAS Number: 23593-75-1 

Molecular Formula: C22H17ClN2 

Molecular Weight: 344.84 

EINECS Number: 245-764-8

Clotrimazole is a synthetic pyrrole antifungal drug, which has inhibitory effect on a variety of pathogenic fungi. It can also have a bactericidal effect when the concentration is high. Clotrimazole inhibits the biosynthesis of fungal ergosterol and other sterols by interfering with the activity of cytochrome P450; damages the fungal cell membrane and changes its permeability, causing the loss of important substances in the cell; it can also inhibit fungal triglycerides and phospholipids The biosynthesis; this product can still inhibit the activity of oxidation and peroxidase, causing excessive accumulation of peroxide in the cell, causing degeneration and necrosis of the fungal subcellular structure. Clotrimazole has a broad-spectrum antifungal activity. It has a good antibacterial effect against Epidermophyton, Trichophyton, Aspergillus, Pigmenting fungus, Cryptococcus and Candida, and against Sporothrix schenckii and dermatitis , Coccidioides spp., Histoplasma spp., etc. also have certain antibacterial activity.