2'-Deoxyadenosine

Melting point 187-189°C

Boiling point 394.4°C(roughestimate)

Density 1.2938 (roughestimate)

Refractive index 1. Chemicalbook 7610 (estimate)

Storage condition 2-8°C form powder

Acidity coefficient (pKa) pK1: 3.8(+1) (25°C, μ=0.1)

effect:

2'-deoxyadenosine is also called 2'-deoxyadenosine (2'-deoxyadenosine, also called β-D-2'-deoxyadenosine), which is a natural deoxyribonucleoside, which is deoxyribose The structural fragment of nucleic acid DNA, like other natural nucleosides, participates in the transmission of genetic information of almost all biological cells, affects the synthesis of proteins and the metabolism of polysaccharides, and is very important for the growth, proliferation, differentiation and inhibition of cells in organisms. An important regulatory role. It is not only an important raw material for genetic medicine and genetic engineering research, but also has good physiological activity. 2'Chemicalbook-deoxyadenosine can inhibit the release of insulin induced by sugar, and can reduce the inhibition of specific phosphodiesterase Or adenosine cyclase activator to promote insulin secretion. In addition, 2'-deoxyadenosine can also be used as an important intermediate of antiviral, anticancer, and anti-AIDS drugs, for example, 2'-fluoro-2'-deoxyadenosine, cladribine (2'-chloro-2' -Deoxyadenosine) has excellent anti-tumor effects, dideoxyadenosine (ddA) has high activity on HIV and HBV viruses, and acyclovir has a strong inhibitory effect on HSV-1 and HSV-2 viruses. These are all important drugs with a large amount in the world.