D-Phenylalanine NEW

D-Phenylalanine Cas 673-06-3

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D-Phenylalanine (D-Phe) is the D-stereoisomer of the essential amino acid phenylalanine.

• Amino Acid Basics: Amino acids are the building blocks of proteins. Most amino acids used by the body are in the "L-" form (e.g., L-Phenylalanine).

  Stereoisomers: L-Phenylalanine and D-Phenylalanine are mirror images of each other, much like a left and right hand. They have the same chemical formula but different three-dimensional structures.

Key Characteristics and Uses

Unlike its L-form, which is incorporated into proteins, D-Phenylalanine is not used for protein synthesis. Its significance comes from its unique biological activities:

1. Enkephalin Inhibition: Its primary researched mechanism is its ability to inhibit enzymes called enkephalinases. These enzymes normally break down enkephalins, which are the body's natural pain-relieving chemicals (endorphins). By blocking these enzymes, D-Phenylalanine may increase the level and duration of enkephalin activity, potentially providing an analgesic effect.

2. Potential Medical Interest:

• Pain Management: Because of its mechanism, it has been studied as a potential complementary therapy for chronic pain conditions.

  Depression: Some research has explored its use in depression, though evidence is limited.

  It is not an FDA-approved drug, but is available as a dietary supplement.

3. Chemical and Research Applications: It is used in scientific research to create specific peptide structures and study biological pathways involving D-amino acids.

In summary, D-Phenylalanine is the non-proteinogenic, mirror-image form of phenylalanine, studied primarily for its potential role in modulating the body's natural pain-control pathways.

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