Capecitabine NEW

Capecitabine Cas 154361-50-9

Specification

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Capecitabine is an oral chemotherapy drug used to treat several types of cancer. It is most commonly known by the brand name Xeloda.

How Does It Work?

Capecitabine is what's known as a prodrug. This means it is inactive when you swallow it. Your body metabolizes it in a 3-step process, primarily in the liver and then within cancer cells, converting it into its active form: 5-Fluorouracil (5-FU).

Once activated, it works by:

1. Inhibiting Thymidylate Synthase: This is a key enzyme needed for DNA replication and repair.

2. Incorporating into RNA/DNA: It gets mistaken for normal building blocks and gets incorporated into RNA and DNA strands.

Both actions disrupt the cancer cell's ability to grow and divide, ultimately causing the cell to die.

What is it Used For?

Capecitabine is used to treat:

• Colorectal Cancer: As adjuvant (post-surgery) therapy and for advanced or metastatic disease.

  Breast Cancer: For metastatic breast cancer, often after other therapies have failed. It is also used in adjuvant settings for certain types of breast cancer.

  Gastric (Stomach) Cancer: For advanced cases.
  It can be used alone or in combination with other chemotherapy drugs.

Key Considerations and Side Effects

• Common Side Effects: Include hand-foot syndrome (redness, pain, and peeling on palms/soles), diarrhea, nausea, vomiting, fatigue, and low blood cell counts.

  Important Warning: Patients with a deficiency in the enzyme DPD (Dihydropyrimidine Dehydrogenase) are at high risk for severe, life-threatening toxicity from Capecitabine (and 5-FU). Testing for this deficiency may be done before starting treatment.

  Administration: It is taken orally in cycles (e.g., two weeks on, one week off) to allow the body to recover.

In short, Capecitabine is a widely used oral chemotherapy that the body converts into an active anti-cancer drug, primarily to treat colorectal and breast cancers.

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Contact information

Spring Zhang

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