27-Hydroxycholesterol NEW
| Price | $43 | $155 | $230 |
| Package | 1mg | 5mg | 10mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-20 |
Product Details
| Product Name: 27-Hydroxycholesterol | CAS No.: 20380-11-4 |
| Purity: 99.45% | Supply Ability: 10g |
| Release date: 2026/05/20 |
Product Introduction
Bioactivity
| Name | 27-Hydroxycholesterol |
| Description | 27-Hydroxycholesterol (25(R)-27-hydroxy Cholesterol) is a selective modulator of estrogen receptor and an agonist of the liver X receptor. |
| In vitro | 27-Hydroxycholesterol activates estrogen receptors, adversely impacting prostate cancer cell lines by significantly enhancing cell proliferation in LNCaP and PC3 cells. This proliferation can be mitigated by estrogen receptor inhibitors [1]. As an endogenous selective estrogen receptor modulator, 27-Hydroxycholesterol exhibits substantial partial agonist activity across various cellular models, notably increasing gene transcription and cell proliferation in breast cancer contexts [2]. Produced from cholesterol by the enzyme CYP27A1, it plays a vital role in regulating intracellular cholesterol equilibrium. Its pro-tumorigenic effects can be diminished by either statins or directly inhibiting CYP27A1 [3]. Furthermore, 27-Hydroxycholesterol's conversion from cholesterol is crucial for LXR activation when faced with cholesterol excess [4]. |
| Storage | Keep away from direct sunlight,Store at low temperature,Store under nitrogen Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMF : 2 mg/mL (4.97 mM), Sonication is recommended. DMSO : 0.1 mg/mL (0.25 mM), Sonication is recommended. 10% EtOH+90% Corn Oil : 1 mg/mL (2.48 mM), Sonication is recommended. Ethanol : ≤ 20 mg/mL (49.66 mM), Sonication is recommended. |
| Keywords | progestogenReceptor | progestogen Receptor | LXR agonist | LXR | LiverXReceptor | Liver X Receptor | EstrogenReceptor | Estrogen Receptor | ER modulator | ER | 27-Hydroxycholesterol | 27Hydroxycholesterol | 27 Hydroxycholesterol | 2527-hydroxy Cholesterol | 25(R)-27-hydroxy Cholesterol |
| Inhibitors Related | Sucrose | Aceglutamide | Nicotinamide riboside malate | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Malic acid | Formamide | Glycerol | Thymidine | Corn starch | Gluconate Calcium | DL-Lysine |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Bioactive Compound Library | Natural Product Library | Endocrinology-Hormone Compound Library | Natural Product Library for HTS | Metabolism Compound Library | Human Endogenous Metabolite Library | Human Endogenous Metabolite Compound Library Plus | Bioactive Compounds Library Max | Bioactive Lipid Compound Library | Human Metabolite Library | Transcription Factor-Targeted Compound Library |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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