3,3-Dichloro-1-(4-nitrophenyl)-2-piperidinone

Apixaban Intermediate 2 (CAS 881386-01-2) | High-Quality Building Block for Anticoagulant API Synthesis‌
‌Google Search Keywords‌: Apixaban Intermediate 2, CAS 881386-01-2, Anticoagulant API Intermediate, Blood Thinner Synthesis, Factor Xa Inhibitor Precursor

🔬 ‌Product Overview‌
Apixaban Intermediate 2 (CAS 881386-01-2) is a vital chemical component in the synthesis of ‌Apixaban‌, a leading direct oral anticoagulant (DOAC) used to prevent strokes and systemic embolism in patients with atrial fibrillation. This intermediate ensures precise and efficient production of high-purity Apixaban API, adhering to strict pharmaceutical standards.
‌Primary Function‌: Enables scalable and cost-effective manufacturing of Apixaban API.
‌Applications‌: Anticoagulant drug production, generic formulations, cardiovascular R&D.

✅ ‌Key Advantages‌
⭐ ‌Ultra-High Purity‌

• Purity ≥99% (HPLC/GC validated), ensuring minimal impurities and batch consistency.

⚙️ ‌Streamlined Synthesis‌

• Reduces synthesis steps by 20-30%, improving yield and lowering production costs.

🌡️ ‌Controlled Stability‌

• Stable under inert storage conditions (2-8°C, argon atmosphere), ideal for long-term use.

📜 ‌Regulatory Alignment‌

• Compliant with ‌ICH Q11‌ and ‌GMP guidelines‌, meeting USP/EP specifications.

📋 ‌Applications‌

1. ‌API Manufacturing‌: Critical precursor in commercial-scale Apixaban production.

2. ‌Generic Drug Development‌: Supports cost-efficient alternatives to branded anticoagulants.

3. ‌Cardiovascular Research‌: Used in studies to optimize Factor Xa inhibitor efficacy.

4. ‌Quality Control‌: Reference standard for impurity profiling and method validation.

🏅 ‌Quality Certifications‌

• Rigorously tested via ‌HPLC, GC, NMR, and Mass Spectrometry‌ (USP/EP/ICH compliant).

• Batch-specific Certificate of Analysis (CoA) with full spectral and chromatographic data.

🌐 ‌Market Trends‌
The global anticoagulant market is projected to grow at ‌8.2% CAGR (2024-2030)‌, fueled by rising cardiovascular disease prevalence and demand for safer DOACs like Apixaban. Intermediate suppliers are pivotal in meeting the surge for generic Apixaban, especially in Asia-Pacific and North American markets.

🔍 ‌Why Choose Us?‌

• ‌Bulk Scalability‌: Production capacity from grams to multi-kilogram batches.

• ‌Custom Synthesis‌: Tailored intermediates with modified purity grades or analytical support.

• ‌Global Logistics‌: Temperature-controlled shipping with regulatory documentation (SDS, CoA).