Product Details
| Product Name:
AGI6780 |
CAS No.:
1432660-47-3 |
| Min. Order:
1G |
Purity:
98% |
| Supply Ability:
100KG |
Release date:
2019/07/06 |
AD68
| AGI6780 Basic information |
| Description In vitro |
| Product Name: |
AGI6780 |
| Synonyms: |
AGI-6780 N-Cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-benzenesulfonamide;N-Cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-benzenesulfonamide AGI-6780;AGI-6780, >=98%;AGI6780;N-cyclopropyl-4-(thiophen-3-yl)-3-(3-(3-(trifluoroMethyl)phenyl)ureido)benzenesulfonaMide;N-Cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-benzenesulfonamide;Benzenesulfonamide, N-cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]- |
| CAS: |
1432660-47-3 |
| MF: |
C21H18F3N3O3S2 |
| MW: |
481.5111296 |
| EINECS: |
|
| Product Categories: |
Inhibitors;API |
| Mol File: |
1432660-47-3.mol |
 |
| |
| AGI6780 Chemical Properties |
| |
| AGI6780 Usage And Synthesis |
| Description |
AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant with IC50 of 23 nM. |
| In vitro |
AGI-6780 potently reduce (R)-2-hydroxyglutarate (2HG) levels in cell lines ectopically overexpressing IDH2/R140Q with EC50 of 20 nM, with excellent selectivity against other dehydrogenases. AGI-6780 reverses the IDH2/R140Q-induced differentiation block in TF-1 cells, and induces blast differentiation in primary human IDH2/R140Q AML patient samples. |
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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