Product Details
| Product Name:
AVL-292 |
CAS No.:
1202757-89-8 |
| Min. Order:
1kg |
Purity:
99% |
| Supply Ability:
100kg |
Release date:
2019/07/06 |
| Product Number::
WM.819 |
| AVL-292 Basic information |
| Product Name: |
AVL-292 |
| Synonyms: |
AVL-292;LMK-435;N-[3-[[5-Fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-2-propenamide;2-Propenamide, N-[3-[[5-fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-;CC-292 (AVL-292);CC-292,LMK-435;N-[3-[[5-Fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-2-propenamide AVL292;CC-292 |
| CAS: |
1202757-89-8 |
| MF: |
C22H22FN5O3 |
| MW: |
423.4401832 |
| EINECS: |
|
| Product Categories: |
Inhibitors |
| Mol File: |
1202757-89-8.mol |
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| AVL-292 Chemical Properties |
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| AVL-292 Usage And Synthesis |
| Uses |
Bruton’s tyrosine kinase (BTK) is a non-receptor tyrosine kinase involved in signal transduction pathways regulating the proliferation, activation, and differentiation of B cells. AVL-292 is an orally available, selective, and irreversible inhibitor of BTK (IC50 = 0.5 nM in vitro in B cell lymphoma cell lines) that targets and covalently binds to BTK at cysteine-481, thereby preventing its activity. AVL-292 has been shown to inhibit osteoclast function and to reduce osteoclast-stimulated proliferation of multiple myeloma cells in animal models of rheumatoid arthritis and multiple sclerosis, both of which are diseases where B cells play an important role. In clinical trials, AVL-292 has demonstrated therapeutic significance in the treatment of both B cell-related cancers (e.g., non-Hodgkin’s lymphoma and B cell chronic lymphocytic leukemia) and autoimmune diseases (e.g., rheumatoid arthritis).[Cayman Chemical] |
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AVL-292 Preparation Products And Raw materials
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Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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![4-CHLORO-5,6-DIMETHYLTHIENO[2,3-D]PYRIMIDINE](https://img.chemicalbook.com/ProductImageEN/2018-12/Large/d5caddb7-6fef-4d11-a3e1-99dc236ef761.png)
China