ACE-031 NEW

ACE-031 (Myostatin inhibitory peptide 7) is a fusion protein of activin receptor type IIB and IgG1-Fc, which binds myostatin and related ligands. ACE-031 promotes muscle growth by binding to myostatin and other negative regulators of muscle mass. ACE-031 was generally well-tolerated. Adverse events included injection site erythema. Mean ACE-031 AUC(0-∞) and C(max) increased linearly with dose; mean T(½) was 10-15 days. Statistically significant increases in mean total body lean mass (3.3%; P = 0.03, by DXA) and thigh muscle volume (5.1%; P = 0.03, by MRI) were observed at day 29 in the 3 mg/kg group. Statistically significant changes in serum biomarkers suggest ACE-031 also improved bone and fat metabolism.

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