ADU-S100 NEW
| Price | Get Latest Price |
| Package | 1removed |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-27 |
Product Details
| Product Name: ADU-S100 | CAS No.: 1638241-89-0 |
| Supply Ability: 10g | Release date: 2025/10/27 |
Product Introduction
Bioactivity
| Name | ADU-S100 |
| Description | ADU-S100 (MIW815) is a cyclic dinucleotide (CDN) class STING agonist that significantly induces the production of IFN-β and pro-inflammatory cytokines TNF-α, IL-6, and MCP-1, induces TBK1 and IRF3 phosphorylation, and exhibits antitumour activity. |
| In vitro | Methods: DCs were treated with ADU-S100 (3.125, 6.25, 12.5, 25, 50, 100, 200 ng/mL) and activated to validate the activity of ADU-S100 and optimize the ideal dose for further assays. Results: The expression of co-stimulatory molecules CD40, CD86, and MHC II increased in a dose-dependent manner, indicating successful DC maturation. [4] |
| In vivo | Methods: SNI male and female mice were treated with ADU-S100 (35 nmol, intrathecal injection), and the expression of IFN-I and induced NF-κB genes in the dorsal horn tissue of mice treated with PBS or ADU-S100 after SNI was analyzed. Results: Transcripts of the proinflammatory cytokines IL-1β, TNFα, and CCL2 showed significant increases only in female mice treated with ADU-S100. [3] |
| Storage | keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 16 mg/mL (23.17 mM), Sonication is recommended. DMSO : 1 mg/mL (1.45 mM), Sonication is recommended. |
| Keywords | STING | MIW-815 | MIW 815 | ADU-S-100 | ADU-S100 | ADUS100 | ADU-S 100 | ADU S100 |
| Inhibitors Related | Acetylcysteine | Acetaminophen | Glucosamine | Gallic Acid Monohydrate | Diclofenac Potassium | Apremilast | trans-Cinnamaldehyde | Paradol | Diallyl disulfide | Phenylbutazone | Revaprazan hydrochloride | Sodium salicylate |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $399.00/1mg |
VIP6Y
|
TargetMol Chemicals Inc.
|
2025-10-21 | |
| $0.00/100mg |
VIP4Y
|
TargetMol Chemicals Inc.
|
2025-06-27 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
INQUIRY