Product Details
| Product Name: Amino-PEG4-alcohol | CAS No.: 86770-74-3 |
| Min. Order: 1kg | Purity: 99% |
| Supply Ability: 100kg | Release date: 2025/10/13 |
| Lead time: in stock | Packaging: bag/bottle/drum//IBC, as request |
| Delivery: By sea, by air, by express | Origin: Manufacturer, advantage products |
| COA, MSDS: Available, contact us for details | Contact: Tina |
PRODUCT INFORMATION
| Common Name | Amino-PEG4-alcohol | ||
|---|---|---|---|
| CAS Number | 86770-74-3 | Molecular Weight | 193.241 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 301.6±27.0 °C at 760 mmHg |
| Molecular Formula | C8H19NO4 | Melting Point | N/A |
| MSDS | N/A | Flash Point | 136.2±23.7 °C |
| Purity | Quantity | Budget | Inquiry |
|---|
Use of Amino-PEG4-alcoholAmino-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Amino-PEG4-alcohol is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. |
| Name | 2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethanol |
|---|---|
| Synonym | More Synonyms |
| Description | Amino-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Amino-PEG4-alcohol is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. |
|---|---|
| Related Catalog | Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker |
| Target | PEGs Non-cleavable |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2]. |
| References | [1]. Nello Mainolfi, et al. Protein degraders and uses thereof. WO2019060742A1. [2]. Miller MA, et al. Modular Nanoparticulate Prodrug Design Enables Efficient Treatment of Solid Tumors Using Bioorthogonal Activation. ACS Nano. 2018 Dec 26;12(12):12814-12826. |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 301.6±27.0 °C at 760 mmHg |
| Molecular Formula | C8H19NO4 |
| Molecular Weight | 193.241 |
| Flash Point | 136.2±23.7 °C |
| Exact Mass | 193.131409 |
| PSA | 73.94000 |
| LogP | -2.09 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.459 |
Material Safety Data Sheet Section1. Identification of the substance Product Name: 1-Amino-3,6,9-trioxaundecanyl-11-ol Synonyms: Section2. Hazards identification Harmful by inhalation, in contact with skin, and if swallowed. Section3. Composition/information on ingredients. Ingredient name:1-Amino-3,6,9-trioxaundecanyl-11-ol CAS number:86770-74-3 Section4. First aid measures Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing contaminated clothing and shoes. If irritation persists, seek medical attention. Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical attention. Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention. Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention. Section5. Fire fighting measures In the event of a fire involving this material, alone or in combination with other materials, use dry powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus should be worn. Section6. Accidental release measures Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national standards. Respiratory precaution:Wear approved mask/respirator Hand precaution:Wear suitable gloves/gauntlets Skin protection:Wear suitable protective clothing Eye protection:Wear suitable eye protection Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container for disposal. See section 12. Environmental precautions: Do not allow material to enter drains or water courses. Section7. Handling and storage Handling:This product should be handled only by, or under the close supervision of, those properly qualified in the handling and use of potentially hazardous chemicals, who should take into account the fire, health and chemical hazard data given on this sheet. Store in closed vessels. Storage: Section8. Exposure Controls / Personal protection Engineering Controls: Use only in a chemical fume hood. Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles. General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse. Section9. Physical and chemical properties Appearance:Not specified Boiling point:No data No data Melting point: Flash point:No data Density:No data Molecular formula:C8H19NO4 Molecular weight:193.2 Section10. Stability and reactivity Conditions to avoid: Heat, flames and sparks. Materials to avoid: Oxidizing agents. Possible hazardous combustion products: Carbon monoxide, nitrogen oxides. Section11. Toxicological information No data. Section12. Ecological information No data. Section13. Disposal consideration Arrange disposal as special waste, by licensed disposal company, in consultation with local waste disposal authority, in accordance with national and regional regulations. Section14. Transportation information Non-harzardous for air and ground transportation. Section15. Regulatory information No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302, or have known CAS numbers that exceed the threshold reporting levels established by SARA Title III, Section 313. SECTION 16 - ADDITIONAL INFORMATION N/A |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| HS Code | 2922509090 |
|---|
 Azido-PEG4-alco... 86770-67-4 ~99%  Amino-PEG4-alco... 86770-74-3 |
| Literature: WISCONSIN ALUMNI RESEARCH FOUNDATION Patent: WO2009/132310 A1, 2009 ; Location in patent: Page/Page column 66 ; |
 2-(2-(2-(2-phth... 90331-86-5 ~% Amino-PEG4-alco... 86770-74-3 |
| Literature: WO2009/108484 A1, ; Page/Page column 24; 25 ; |
 2,2'-((Oxyb... 112-60-7 ~% Amino-PEG4-alco... 86770-74-3 |
| Literature: Journal of the American Chemical Society, , vol. 125, # 5 p. 1120 - 1121 |
| Precursor 9 | Previous 1/3 Next |
|---|---|
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| DownStream 2 | |
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CAS#:77544-60-6
CAS#:7732-18-5
CAS#:106984-09-2
CAS#:437655-95-3| HS Code | 2922509090 |
|---|---|
| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
| 2-{2-[2-(2-Aminoethoxy)ethoxy]ethoxy}ethanol |
| 2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethanol |
| Ethanol, 2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]- |
Company Profile
Our company is a high-tech enterprise specializing in chemical raw materials such as electronic materials, optoelectronic materials, semiconductor materials, UV monomers, silane catalysts, cosmetic raw materials, etc. The company integrates research and development, production, customized synthesis, and sales, and is committed to providing customers with high-quality chemical product solutions.
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Our products have been exported to many countries, including Germany, Spain, the United Kingdom, the United States, Australia, the Middle East, Asia, and more. We have received highly positive feedback from our clients and have established long-term friendly cooperative relationships with them.
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• Packaging:
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Contact name: Tina
Email address: Tina@fdachem.com
Mob: 86 13213167925
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Company Profile Introduction
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