Product Details
| Product Name:
Azelaprag |
CAS No.:
2049980-18-7 |
| Purity:
98.04% |
Supply Ability:
10g |
| Release date:
2026/07/31 |
Product Introduction
Bioactivity
| Name | Azelaprag |
| Description | Azelaprag (AMG 986) is an oral apelin receptor agonist (EC50 = 0.32 nM). Azelaprag may be used to treat neurological disorders, cardiovascular diseases, and obesity with metabolic syndrome. |
| In vitro | Methods: Primary human ADPKD renal epithelial cells were cultured in 3D collagen matrices and treated with 1 nmol/L to 1 μmol/L of Azelaprag; cyst growth was then assessed.
Results: Azelaprag inhibited cyst volume in a dose-dependent manner and reduced the number of cysts. [3] |
| In vivo | Methods: Pkd1^(RC/RC);Pkd2^(+/-) polycystic kidney mice were administered 2 mg/kg of Azelaprag via intraperitoneal injection daily for 27 days.
Results: Azelaprag reduced cyst count but did not significantly improve the corticomedullary ratio, cyst index, or renal function. [3] |
| Storage | Store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 69.3 mg/mL (132.35 mM), Sonication is recommended.
|
| Keywords | Azelaprag | Apelinreceptor | Apelin receptor | AMG-986 | AMG986 |
| Inhibitors Related | 1-Methyl-3-phenylpropylamine | ML339 | ELA-14(human) acetate | BMS-986224 | ELA-11 (human) acetate(1784687-32-6 free base) | Apelin-12 acetate | APJ receptor agonist 8 | AM-8123 | (2R,3S)-Azelaprag | [Pyr1]-Apelin-13 | CMF019 | ML221 |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | ReFRAME Related Library | Bioactive Compound Library Plus | Drug Repurposing Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$107.00
|
VIP7Y
|
TargetMol Chemicals Inc.
|
2026-07-31 |
United States