Batimastat sodium salt NEW
| Price | $1520 |
| Package | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-08-21 |
Product Details
| Product Name: Batimastat sodium salt | CAS No.: 130464-84-5 |
| Supply Ability: 10g | Release date: 2025/08/21 |
Product Introduction
Bioactivity
| Name | Batimastat sodium salt |
| Description | Batimastat (BB-94) sodium salt is a broad-spectrum MMP inhibitor (IC50s: 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7, and MMP-3). |
| Cell Research | http://www.ncbi.nlm.nih.gov/pubmed/19889233 |
| Kinase Assay | 6. Russo LA, et al. Regulated expression of matrix metalloproteinases, inflammatory mediators, and endometrial matrix remodeling by 17beta-estradiol in the immature rat uterus. Reprod Biol Endocrinol. 2009 Nov 4;7:124. |
| In vitro | Batimastat inhibits gelatinases A and B (IC50s: 4 nM and 10 nM). The IC50 with the structurally similar collagenase Ht-d is 6 nM, which is comparable with values for MMP-1 (3 nM), MMP-8 (10 nM), and MMP-3 (20 nM) [2]. CD30 shedding from the cell line Karpas299 can effectively be blocked by the hydroxamic acid-based metalloproteinase inhibitor Batimastat (IC50: 230 nM) [3]. |
| In vivo | Matrix density in animals treated with saline or Batimastat (40 mg/kg) is analyzed 4 hours post-E2 administration, a critical point when collagen density notably decreases following hormone treatment [6]. Batimastat intraperitoneally administers to restrict human ovarian carcinoma xenografts and murine melanoma metastasis, alongside delaying primary tumor growth in human breast cancer models without inducing cytotoxicity or affecting mRNA levels [2]. Exhibiting antineoplastic and antiangiogenic effects across tumor models, Batimastat's concomitant application with Cisplatin (60 mg/kg i.p. bi-daily for 8 injections and 4 mg/kg i.v. every 7 days for 3 injections, respectively) effectively halts growth and dissemination of xenografts, maintaining all subjects' health up to day 200 [4]. Furthermore, Kaplan-Meier survival analysis (48 hours) highlights a significant survival rate increase to 95.2% in Batimastat-treated animals versus 75% in controls, with statistical relevance nearing significance (p=0.064) [5]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | MMP-9 | MMP-7 | MMP-3 | MMP-2 | MMP-1 | BB-94 sodium | Batimastat sodium salt | Batimastat sodium |
| Inhibitors Related | Stigmasterol | Ethyl gallate | Doxycycline (hyclate) | Astragaloside IV | Doxycycline | Edaravone | Glucosamine | Bovine Type II Collagen | Triolein | Arctigenin | Fenofibric acid | Glucosamine sulfate |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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