Batimastat sodium salt NEW
| Price | $1520 |
| Package | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-08-22 |
Product Details
| Product Name: Batimastat sodium salt | CAS No.: 130464-84-5 |
| Supply Ability: 10g | Release date: 2025/08/22 |
Product Introduction
Bioactivity
| Name | Batimastat sodium salt |
| Description | Batimastat (BB-94) sodium salt is a broad-spectrum MMP inhibitor (IC50s: 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7, and MMP-3). |
| Cell Research | http://www.ncbi.nlm.nih.gov/pubmed/19889233 |
| Kinase Assay | 6. Russo LA, et al. Regulated expression of matrix metalloproteinases, inflammatory mediators, and endometrial matrix remodeling by 17beta-estradiol in the immature rat uterus. Reprod Biol Endocrinol. 2009 Nov 4;7:124. |
| In vitro | Batimastat inhibits gelatinases A and B (IC50s: 4 nM and 10 nM). The IC50 with the structurally similar collagenase Ht-d is 6 nM, which is comparable with values for MMP-1 (3 nM), MMP-8 (10 nM), and MMP-3 (20 nM) [2]. CD30 shedding from the cell line Karpas299 can effectively be blocked by the hydroxamic acid-based metalloproteinase inhibitor Batimastat (IC50: 230 nM) [3]. |
| In vivo | Matrix density in animals treated with saline or Batimastat (40 mg/kg) is analyzed 4 hours post-E2 administration, a critical point when collagen density notably decreases following hormone treatment [6]. Batimastat intraperitoneally administers to restrict human ovarian carcinoma xenografts and murine melanoma metastasis, alongside delaying primary tumor growth in human breast cancer models without inducing cytotoxicity or affecting mRNA levels [2]. Exhibiting antineoplastic and antiangiogenic effects across tumor models, Batimastat's concomitant application with Cisplatin (60 mg/kg i.p. bi-daily for 8 injections and 4 mg/kg i.v. every 7 days for 3 injections, respectively) effectively halts growth and dissemination of xenografts, maintaining all subjects' health up to day 200 [4]. Furthermore, Kaplan-Meier survival analysis (48 hours) highlights a significant survival rate increase to 95.2% in Batimastat-treated animals versus 75% in controls, with statistical relevance nearing significance (p=0.064) [5]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | MMP-9 | MMP-7 | MMP-3 | MMP-2 | MMP-1 | BB-94 sodium | Batimastat sodium salt | Batimastat sodium |
| Inhibitors Related | Stigmasterol | Ethyl gallate | Doxycycline (hyclate) | Astragaloside IV | Doxycycline | Edaravone | Glucosamine | Bovine Type II Collagen | Triolein | Arctigenin | Fenofibric acid | Glucosamine sulfate |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $48.00/1mg |
VIP6Y
|
TargetMol Chemicals Inc.
|
2025-10-17 | |
| $5.00/1KG |
VIP2Y
|
Henan Fengda Chemical Co., Ltd
|
2024-04-16 | |
| $50.00/1kg |
VIP4Y
|
Hebei Dangtong Import and export Co LTD
|
2023-10-08 | |
| $1520.00/25mg |
VIP4Y
|
TargetMol Chemicals Inc.
|
2025-08-21 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
INQUIRY