Berberine NEW
| Price | $50 |
| Package | 20mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-31 |
Product Details
| Product Name: Berberine | CAS No.: 2086-83-1 |
| Purity: 99.67% | Supply Ability: 10g |
| Release date: 2025/10/31 |
Product Introduction
Bioactivity
| Name | Berberine |
| Description | 1. Berberine (Umbellatine) is a potent oral hypoglycemic agent with beneficial effects on lipid metabolism. 2. Berberine may as a broad-spectrum anti-microbial medicine, a complementary therapeutic agent for HIV/AIDS. 3. Berberine seems to act as an herbal antidepressant and a neuroprotector against neurodegenerative disorders. 4. Berberine is used in histology for staining heparin in mast cells. As a natural dye, berberine has a colour index of 7516. 5. Berberine reduces hepatic fat content in rats with nonalcoholic fatty liver disease; also prevents proliferation of hepatic stellate cells (HSCs), which are central for the development of fibrosis during liver injury. 6. Berberine can ameliorate proinflammatory cytokines-induced intestinal epithelial tight junction damage in vitro, and berberine may be one of the targeted therapeutic agents that can restore barrier function in intestinal disease states. 7. Berberine has antineoplastic effects, including breast cancer, leukemia, melanoma, epidermoid carcinoma, hepatoma, pancreatic cancer, oral carcinoma, tongue carcinoma, glioblastoma, prostate carcinoma and gastric carcinoma, etc. |
| In vitro | METHODS: Human osteosarcoma cells MG-63 were treated with Berberine (20-80 µM) for 12-24 h. Cell viability was measured by MTT assay. RESULTS: Berberine induced a concentration- and time-dependent decrease in MG-63 cell viability. [1] METHODS: The NPC cell line HONE1 was treated with Berberine (25-50 µM) for 24 h, and the expression levels of target proteins were measured by Western Blot. RESULTS: Berberine effectively inhibited the level of p-STAT3 in HONE1 cells, and the down-regulation of STAT3 activation was associated with the inhibition of Mcl-1 expression and an increase in cleaved PARP-1 levels. [2] |
| In vivo | METHODS: To test the antitumor activity in vivo, Berberine (5-10 mg/kg) was injected intraperitoneally every two days for thirty days into nude mice bearing NPC tumor C666-1. RESULTS: Berberine effectively inhibited the tumorigenicity and growth of EBV-positive NPC cell line (C666-1) in nude mice. Inhibition of tumorigenic growth of NPC cells in vivo correlated with effective inhibition of STAT3 activation in NPC cells within tumor xenografts in nude mice. [2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2.05 mg/mL (6.09 mM), Suspension. Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc. : Soluble DMSO : 9.8 mg/mL (29.14 mM), Sonication is recommended. H2O : < 1 mg/mL (insoluble or slightly soluble) |
| Keywords | Topoisomerase | ReactiveOxygenSpecies | Reactive Oxygen Species | Natural Yellow-18 | Natural Yellow18 | Natural Yellow 18 | Inhibitor | inhibit | EndogenousMetabolite | Endogenous Metabolite | Berberine | Bacterial | Autophagy | Antibiotic | Antibacterial |
| Inhibitors Related | Sucrose | Neomycin sulfate | Ethoxyquin | Aceglutamide | Emtricitabine | D(+)-Raffinose pentahydrate | 2-Amino-2-methyl-1-propanol | Tributyrin | Glycerol | Thymidine | Sodium 2-hydroxybutanoate | BES |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Alkaloid Natural Product Library | Selected Plant-Sourced Compound Library | Drug Repurposing Compound Library | Natural Product Library | Neuroprotective Compound Library | Anti-infective Natural Product Library | Immunology/Inflammation Compound Library | Bitter Compound library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Food as Medicine Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $1.00/1KG |
VIP6Y
|
Shaanxi Dideu Medichem Co. Ltd
|
2025-09-08 | |
| $100.00/1KG |
VIP6Y
|
Sichuan Zhuoyu Yantang Technology Co., Ltd.
|
2025-09-08 | |
| $0.00/1kg |
VIP1Y
|
Chongqing Soarwin Technology Co., Ltd
|
2025-04-11 | |
| $1.00/1kg |
VIP4Y
|
Huzhou Haipu Chemical Co.,Ltd
|
2025-01-09 | |
| $150.00/1kg |
VIP1Y
|
Hebei Zhuanglai Chemical Trading Co Ltd
|
2024-12-09 | |
| $999.00/5kg |
VIP2Y
|
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
|
2024-08-14 | |
| $0.10/1KG |
VIP6Y
|
Shaanxi Dideu Medichem Co. Ltd
|
2024-07-18 | |
| $90.00/1kg |
Guangzhou Tengyue Chemical Co., Ltd.
|
2024-04-13 | ||
| $0.00/1kg |
Hebei Yanxi Chemical Co., Ltd.
|
2023-09-08 | ||
| $45.00/1kg |
Anhui Ruihan Technology Co., Ltd
|
2023-08-23 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
INQUIRY