Product Details
| Product Name:
BRD5529 |
CAS No.:
1358488-78-4 |
| Supply Ability:
10g |
Release date:
2026/07/27 |
Product Introduction
Bioactivity
| Name | BRD5529 |
| Description | BRD5529 is a selective inhibitor of the CARD9-E3 ubiquitin ligase TRIM62 protein-protein interaction, with an IC50 value of 8.6 μM. BRD5529 directly and selectively binds CARD9, disrupts TRIM62 recruitment, inhibits TRIM62-mediated ubiquitinylation, and suppresses CARD9 activation. BRD5529 is therefore applicable to investigations involving innate immune signaling, ubiquitination pathways, inflammatory regulation, and CARD9-associated immune responses. |
| In vitro | BRD5529 exhibits potent dose-dependent inhibitory activity against the CARD9-TRIM62 interaction, with an IC50 value of 8.6 μM[1].
BRD5529 (200 μM, 0–50 min; 200 μM, 2–4 h) suppresses CARD9-dependent signaling in innate immune cells[1]. BRD5529 (40 μM) dose-dependently inhibits TRIM62-mediated CARD9 ubiquitination in vitro[1]. |
| In vivo | BRD5529 (0.1 or 1.0 mg/kg; i.p.; daily, for 2 weeks) does not produce significant changes in daily or final weight gain, shows no major differences in proinflammatory cytokine levels, and does not cause significant alterations in lung, liver, or kidney pathology scores of Pneumocystis pneumonia (PCP) mice model[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 100 mg/mL (214.8 mM), Sonication is recommended.
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| Keywords | CARD9-E3 ubiquitin ligase TRIM62 | BRD5529 |
| Inhibitors Related | T521 | NAcM-OPT | Nutlin-3 | Yucasin | BC-1293 | EN219 | NSC232003 | Auxinole | Indole-3-carbinol | Idasanutlin | TRIM25 ligand-1 | Direct Black 38 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
| Product name |
Price |
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Suppliers |
Update time |
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$52.00
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VIP3Y
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TargetMol Chemicals Inc.
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2026-07-27 |
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$52.00
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VIP3Y
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TargetMol Chemicals Inc.
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2025-08-22 |
United States