BRD5529 NEW
| Price | $52 |
| Package | 2mg |
| Supply Ability: | 10g |
| Update Time: | 2026-07-27 |
Product Details
| Product Name: BRD5529 | CAS No.: 1358488-78-4 |
| Supply Ability: 10g | Release date: 2026/07/27 |
Product Introduction
Bioactivity
| Name | BRD5529 |
| Description | BRD5529 is a selective inhibitor of the CARD9-E3 ubiquitin ligase TRIM62 protein-protein interaction, with an IC50 value of 8.6 μM. BRD5529 directly and selectively binds CARD9, disrupts TRIM62 recruitment, inhibits TRIM62-mediated ubiquitinylation, and suppresses CARD9 activation. BRD5529 is therefore applicable to investigations involving innate immune signaling, ubiquitination pathways, inflammatory regulation, and CARD9-associated immune responses. |
| In vitro | BRD5529 exhibits potent dose-dependent inhibitory activity against the CARD9-TRIM62 interaction, with an IC50 value of 8.6 μM[1]. BRD5529 (200 μM, 0–50 min; 200 μM, 2–4 h) suppresses CARD9-dependent signaling in innate immune cells[1]. BRD5529 (40 μM) dose-dependently inhibits TRIM62-mediated CARD9 ubiquitination in vitro[1]. |
| In vivo | BRD5529 (0.1 or 1.0 mg/kg; i.p.; daily, for 2 weeks) does not produce significant changes in daily or final weight gain, shows no major differences in proinflammatory cytokine levels, and does not cause significant alterations in lung, liver, or kidney pathology scores of Pneumocystis pneumonia (PCP) mice model[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 100 mg/mL (214.8 mM), Sonication is recommended. |
| Keywords | CARD9-E3 ubiquitin ligase TRIM62 | BRD5529 |
| Inhibitors Related | T521 | NAcM-OPT | Nutlin-3 | Yucasin | BC-1293 | EN219 | NSC232003 | Auxinole | Indole-3-carbinol | Idasanutlin | TRIM25 ligand-1 | Direct Black 38 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $52.00 |
VIP4Y
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TargetMol Chemicals Inc.
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2026-07-27 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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