CCT365623 hydrochloride NEW
| Price | $1820 | $2380 | $3100 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-18 |
Product Details
| Product Name: CCT365623 hydrochloride | CAS No.: 2126136-98-7 |
| Supply Ability: 10g | Release date: 2025/07/18 |
Product Introduction
Bioactivity
| Name | CCT365623 hydrochloride |
| Description | CCT365623 hydrochloride is an orally active lysyl oxidase (LOX) inhibitor with an IC50 of 0.89 μM and suppresses EGFR (pY1068) and AKT phosphorylation induced by EGF. |
| In vitro | CCT365623 inhibits LOX at approximately 5 μM in the biosensor system. CCT365623 (0-40 μM) decreases surface EGFR protein levels in a concentration-dependent manner, disrupts HTRA1 multimerization, activates [TGFβ1] signaling, suppresses MATN2 expression, and reduces EGFR surface retention and signaling. At 5 μM, CCT365623 decreases pY1068 EGFR, pAKT, and MATN2 protein levels, while increasing pSMAD2 protein levels. |
| In vivo | CCT365623 (70 mg/kg, oral gavage per day) significantly delays the development of the primary tumors and also suppresses metastatic lung burden in the animals. CCT365623 disrupts EGFR cell surface retention and delays the growth of primary and metastatic tumor cells. CCT365623 exhibits a T1/2PO of 0.6 h and F% (oral bioavailability) of 45%. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | LOX | CCT-365623 hydrochloride | CCT-365623 Hydrochloride | CCT365623 Hydrochloride | CCT365623 hydrochloride | CCT 365623 Hydrochloride |
| Inhibitors Related | 2,5-Di-tert-butylhydroquinone | Caffeic Acid | 5-LOX inhibitor | Diethylcarbamazine citrate | Setileuton | Phenidone | Abietic Acid | Resveratrol | NNK | PF-4191834 | 5-Aminosalicylic Acid | Malotilate |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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