Chlortalidone Impurity NEW

Chlortalidone Impurity; 955-16-8

WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com

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• Chlortalidone Impurity 3

• Product Information

• Product Code: C138003

• English Name: Chlortalidone Impurity 3

• English Alias: 5-phenylisobenzofuran-1,3-dione

• CAS No.：955-16-8

• Molecular Formula: C₁₄H₈O₃

• Molecular Weight: 224.21

• Advantages

• Purity Assurance: HPLC ≥99.5%, confirmed by IR and melting point analysis.

• Stability: Shelf life of 36 months at room temperature, with <0.1% degradation in ethyl acetate.

• Regulatory Compliance: Meets ICH Q3A for organic impurities in diuretics.

• Applications

• Residual Impurity Control: Detects benzofuranone in Chlortalidone via GC-MS.

• Process Optimization: Monitors decarboxylation side reactions during synthesis.

• Method Validation: Validates GC methods for volatile impurities.

• Background Description

• This impurity originates from thermal degradation or cyclization of benzoic acid intermediates. It requires control due to potential genotoxicity concerns.

• Research Status

• Detection: GC-MS with DB-5 column; LOD: 1 ppm.

• Formation: Induced by high-temperature reaction steps; reducing reaction temperature lowers content by 80%.

• Toxicity: Ames test shows no mutagenicity; further genotoxicity studies ongoing.

NOTE！

We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!

WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com

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