Chlortalidone Impurity NEW

Chlortalidone Impurity; 13450-37-8

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E-mail: anna@molcoo.com

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• Chlortalidone Impurity 2

• Product Information

• Product Code: C138002

• English Name: Chlortalidone Impurity 2

• English Alias: 2-(3-chlorobenzoyl)benzoic acid

• CAS No.：13450-37-8

• Molecular Formula: C₁₄H₉ClO₃

• Molecular Weight: 260.67

• Advantages

• High Purity & Structural Confirmation: HPLC ≥99.0%, validated by NMR and HRMS.

• Stability: Stable for 24 months at -20℃, with <0.3% degradation in methanol.

• Regulatory Compliance: Meets EP/USP standards for diuretic impurity control.

• Applications

• Impurity Detection: Quantifies Impurity 2 in Chlortalidone formulations via LC-MS.

• Synthesis Monitoring: Tracks 3-chlorobenzoyl residue during ring closure reactions.

• Method Validation: Supports specificity testing for chromatographic methods.

• Background Description

• This impurity forms from isomeric chlorobenzoyl reagents in Chlortalidone synthesis. Controlling positional isomers is critical for drug quality.

• Research Status

• Detection: HPLC with C18 column (5μm) and gradient elution; LOD: 0.05 μg/mL.

• Formation Mechanism: Results from ortho/meta chlorination selectivity; using catalyzed chlorination reduces meta-isomer by 65%.

• Safety Evaluation: Acute toxicity tests show no adverse effects; chronic studies in progress.

NOTE！

We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!

WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com

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