Cyclophosphamide NEW
| Price | $35 | $51 | $142 |
| Package | 50mg | 100mg | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-09-09 |
Product Details
| Product Name: Cyclophosphamide | CAS No.: 50-18-0 |
| Purity: 100.00% | Supply Ability: 10g |
| Release date: 2025/09/09 |
Product Introduction
Bioactivity
| Name | Cyclophosphamide |
| Description | Cyclophosphamide is an alkylating agent type of anti-tumor drug, and its main target is DNA. Cyclophosphamide inhibits the proliferation of tumor cells by undergoing alkylation reactions with DNA, interfering with the replication and transcription processes of DNA. |
| In vitro | METHODS: Human HL60 cells were treated with Cyclophosphamide, and cytotoxicity was detected by the MTT method. RESULTS: Cyclophosphamide inhibited the growth of HL60 cells, with an IC50 of 8.79 μM. [1] METHODS: Human K562 cells were treated with Cyclophosphamide for 48 hours, and the cell growth inhibition was detected by the MTT method. RESULTS: Cyclophosphamide inhibited the growth of K562 cells, with an IC50 of 0.153 μM. METHODS: Human MCF7 cells were treated with Cyclophosphamide for 48 hours, and cytotoxicity was detected using the SRB method. RESULTS: Cyclophosphamide inhibited the growth of K562 cells, with an IC50 of 10 mM. [2] METHODS: COS-1 cells and HCT-15 cells were treated with Cyclophosphamide for 24 hours, and cytotoxicity was detected by the MTT method. RESULTS: Cyclophosphamide inhibited the growth of COS-1 cells (IC50=125.43 μM) and HCT-15 cells (IC50=74.32 μM). [3] METHODS: DU-145 cells were treated with Cyclophosphamide, and cytotoxicity was detected by the MTT method. RESULTS: Cyclophosphamide inhibited DU-145 cells (IC50=52.5 μM). [4] METHODS: HCT-15 cells and HEK-293T cells were treated with Cyclophosphamide for 24 hours, and the cell growth inhibition was detected by the MTT method. RESULTS: Cyclophosphamide inhibited the growth of COS-1 cells (IC50=76.32 μM) and did not inhibit the growth of HEK-293T cells (IC5> 100 μM). [5] |
| In vivo | METHODS: Cyclophosphamide induces ovarian insufficiency (POI) by activating primordial follicles. Cyclophosphamide (150 mg/kg; Intraperitoneal injection A single dose was injected into 5-week-old female Balb/C mice. RESULTS: The number of primary follicles in the ovaries decreases. [6] METHODS: Cyclophosphamide induces bone marrow suppression by interfering with the proliferation and differentiation of bone marrow (BM) cells. Cyclophosphamide (150 mg/kg; Intraperitoneal injection A single dose was injected into 56-week-old male Swiss mice. RESULTS: It causes significant changes in the structure of bone marrow tissue, reduces the bone marrow/red blood cell ratio, and decreases the number of white blood cells in the blood. [7] |
| Storage | store at low temperature,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 33.33 mg/mL (127.66 mM), Sonication is recommended. DMSO : 255 mg/mL (976.67 mM), The compound is unstable in solution, please use soon. |
| Keywords | MRP1 | Inhibitor | inhibit | DNAAlkylator | DNA Alkylator/Crosslinker | DNA Alkylator | DNA | Cyclophosphamide | Crosslinker |
| Inhibitors Related | Prednisone | Busulfan | N-Nitroso-N-methylurea | Lisinopril dihydrate | Methoxsalen | Oxaliplatin | Temozolomide | Benzocaine | Flurbiprofen | Clarithromycin | Cisplatin | Crystal Violet |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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