Dequalinium Impurity 16(Hydrochloride) NEW

Product Information

Product Number: D023016A

English Name: Dequalinium Impurity 16(Hydrochloride)

English Alias: 2-methyl-N-phenylquinolin-4-amine hydrochloride

CAS Number: 879662-14-3

Molecular Formula: C₁₆H₁₄N₂.HCl

Molecular Weight: 234.30 36.46

Advantages

Well-defined and distinct structure: Contains quinoline ring, methyl group, N-phenylamino group, and hydrochloride moiety, lacking the bis-quinoline and long-chain linkage of dequalinium. Synergistic effects of quinoline conjugation, amine, and chloride enable unique polarity and retention, allowing accurate identification via HPLC and LC-MS as a specific impurity marker;

High stability and traceability: Quinoline-amine conjugation and hydrochloride ionic bonding ensure stability under acidic conditions. As an incomplete condensation by-product in dequalinium synthesis, it directly reflects amination efficiency, improving process tracing accuracy;

High detection sensitivity: Strong UV absorption (260-280nm) from quinoline, combined with characteristic mass response of free base (m/z 235 [M+H]⁺), enables trace analysis via LC-MS (ppb level), compatible with bis-quinoline disinfectant impurity systems.

Applications

Pharmaceutical quality control: Used as a reference standard to quantify Dequalinium Impurity 16(Hydrochloride) in APIs and formulations, ensuring residual mono-quinoline impurities meet quality standards;

Synthesis optimization: Optimizing 2-methylquinoline-aniline amination (catalyst, temperature) by monitoring impurity levels to enhance bis-quinoline condensation efficiency;

Impurity profile enrichment: Contributing to dequalinium’s impurity profile for comprehensive purity assessment and regulatory submissions.

Background Description

Research Status

Analytical method validation: Developing UPLC-MS/MS assays with hydrochloride-optimized parameters for simultaneous quantification of impurity and dequalinium, achieving 0.1 ppb detection limits;

Condensation kinetics: Studying impurity formation under varying reactant ratios to clarify bis-quinoline synthesis mechanisms;

Process refinement: Controlling impurity levels below 0.1% via optimized condensation conditions to enhance API purity;

Formulation compatibility: Evaluating interactions between the impurity and excipients to ensure stability of dequalinium formulations during shelf life