Dextran sulfate sodium salt (MW 36,000 - 50,000) NEW
| Price | $30 | $53 |
| Package | 100mg | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-16 |
Product Details
| Product Name: Dextran sulfate sodium salt (MW 36,000 - 50,000) | Supply Ability: 10g |
| Release date: 2025/10/16 |
Product Introduction
Bioactivity
| Name | Dextran sulfate sodium salt (MW 36,000 - 50,000) |
| Description | Dextran sulfate sodium salt (MW 36,000–50,000) is a medium molecular weight polyanionic dextran derivative with strong intestinal epithelial permeability. It is the most commonly used agent for inducing inflammatory bowel disease (IBD) models, effectively inducing both acute and chronic colitis. Its mechanism may involve macrophage dysfunction and gut microbiota dysbiosis. Due to its colonic epithelial toxicity, long-term use can also induce colorectal cancer models. |
| In vivo | Method: To induce acute colitis, Dextran Sulfate Sodium Salt (MW 36,000-50,000) was administered via drinking water at a concentration of 2.8% (m/V) for 6 consecutive days (from day 0 to day 6). Results: Compared with the control group, mice in the DSS-induced colitis group exhibited severe clinical symptoms, including significant weight loss, increased DAI scores, and shortened colon length. H&E staining of colon tissue sections from the DSS group revealed inflammatory cell infiltration, goblet and epithelial cell loss, crypt abscesses, thickened and detached muscular layers, and a marked increase in ulcer formation. Additionally, histopathological analysis showed significant colonic tissue damage. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 100 mg/mL, Sonication is recommended. |
| Keywords | Dextran sulfate sodium salt (MW40000) | Dextran sulfate sodium salt (MW 36000-50000) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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