Product Details
| Product Name:
F15845 |
CAS No.:
470454-73-0 |
| Supply Ability:
10g |
Release date:
2025/10/27 |
Product Introduction
Bioactivity
| Name | F15845 |
| Description | F 15845 is a potent and persistent blocker of the sodium current. It possesses cardioprotective properties and exhibits both anti-ischemic activity and short- and long-term cardioprotection following myocardial infarction. Furthermore, F 15845 finds utility in the investigation of myocardial functional impairment [1]. |
| In vitro | F 15845, at concentrations ranging from 10 nM to 10 μM, has been shown to concentration-dependently mitigate veratrine-induced diastolic contracture in isolated atria, with an IC50 value of 0.14 μM [1]. Additionally, when administered at 0.1 to 10 μM, it effectively preserves the viability of isolated cardiomyocytes challenged with lysophosphatidylcholine (LPC) [1]. At a specific concentration of 0.3 μM, F 15845 significantly counteracts the increase in sodium levels ([Na+]) observed during no-flow ischemia, and when applied at the same concentration over a duration of 0-35 minutes, it not only delays the reduction in [Na+] but also prominently marks and sustains it upon reperfusion [1]. |
| In vivo | F 15845, administered intravenously at doses of 5 mg/kg, demonstrates significant cardioprotective effects in anesthetized rats. This includes a substantial reduction in infarct size, a decrease in troponin I levels, and the prevention of long-term infarct size expansion, underscoring its potential therapeutic benefits in cardiac injury models. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Inhibitors Related | Pramocaine hydrochloride | Phenytoin sodium | Procaine | Tetracaine hydrochloride | Lidocaine | Safinamide | Valproic Acid | L-Aspartic aicd sodium | Lidocaine hydrochloride | Mebeverine hydrochloride | Dibucaine | Ropivacaine hydrochloride |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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Recommended supplier
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Anhui Ruihan Technology Co., Ltd
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