GABAA receptor agent 8 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-27 |
Product Details
| Product Name: GABAA receptor agent 8 | CAS No.: 2376841-54-0 |
| Supply Ability: 10g | Release date: 2025/10/27 |
Product Introduction
Bioactivity
| Name | GABAA receptor agent 8 |
| Description | GABAA receptor agent 8 (compound 5e) is a potent positive modulator of the GABAA receptor, exhibiting anticonvulsant activity in both in vitro and in vivo studies, with low neurotoxicity, indicating its potential in epilepsy research [1]. |
| In vitro | GABAA receptor agent 8 (compound 5e) demonstrates anticonvulsant activity, evidenced by an IC50 of 0.334 μM in the 4-AP induced hyper-excitability model [1]. Additionally, this compound enhances GABA-induced activation of the GABAA1 receptor in a dose-dependent manner over a range of 0.01-100 μM and a duration of 0-140 seconds, with an EC50 of 12.02 μM. |
| In vivo | GABAA receptor agent 8 (compound 5e) demonstrates anticonvulsant efficacy in mice, exhibiting an effective dose (ED50) of 40.95 mg/kg and a toxic dose (TD50) of 372.39 mg/kg [1]. This agent specifically mitigates seizures induced by pentylenetetrazol (PTZ) without affecting those caused by maximal electroshock (MES) in mice [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Inhibitors Related | Compound PDK0243 | p-Hydroxybenzaldehyde | Urethane | Baicalin | Penicillin G sodium salt | DL-Pyroglutamic acid | Valproic Acid | Halothane | Chlorothymol | (-)-α-Pinene | Dihydromyricetin | Methionine |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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