Histamine NEW
| Price | $34 | $48 |
| Package | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2026-05-15 |
Product Details
| Product Name: Histamine | CAS No.: 51-45-6 |
| Purity: 99.87% | Supply Ability: 10g |
| Release date: 2026/05/15 |
Product Introduction
Bioactivity
| Name | Histamine |
| Description | Histamine (Ergamine) is an amine derived from histamine through enzymatic decarboxylation; it acts as a histamine receptor agonist and vasodilator. Histamine is an organic nitrogen compound that participates in local immune responses and regulates intestinal physiological functions. Histamine is a potent stimulant of gastric secretion, a bronchoconstrictor, a vasodilator, and a centrally acting neurotransmitter. Histamine influences the p38 MAPK/Akt signaling pathway and exhibits antitumor, antioxidant, and anti-inflammatory activities. Histamine can be used in research on acute myeloid leukemia, malignant melanoma, and renal cell carcinoma. |
| In vitro | Methods: Sympathetic preganglionic neurons (SPNs) in thoracolumbar spinal cord slices from newborn (6–14 days old) Wistar Kyoto rats were perfused with histamine (100 μM) for 15–120 seconds in the bath. Whole-cell current clamp recordings measured membrane potential and input resistance changes. Results: Histamine treatment induced depolarization in 69.6% (16/23) of cells (mean 4.5 mV), accompanied by an increase in input resistance (16.9%).[1] |
| In vivo | Methods: Adult C57BL/6J mice were first administered LPS (1 or 2 mg/kg) via intraperitoneal injection. Two days later, they received an intracerebroventricular injection of histamine (100 μM) or a control solution into the hippocampus. After an additional two days, the mice were euthanized. Western blot analysis was performed to detect hippocampal tissue levels of GFAP (astrocytes) and Iba-1 (microglia) proteins. Results: LPS (2 mg/kg) alone significantly increased GFAP and Iba-1 expression. Histamine treatment significantly reversed LPS-induced elevation of GFAP and Iba-1. [2] |
| Storage | Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 260 mg/mL (2339.18 mM), Sonication is recommended. |
| Keywords | Inhibitor | inhibit | HT | HistamineReceptor | Histamine Receptor | Histamine | EndogenousMetabolite | Endogenous Metabolite | 5HTReceptor | 5HT Receptor |
| Inhibitors Related | Sucrose | Aceglutamide | Nicotinamide riboside malate | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Malic acid | Formamide | Glycerol | Thymidine | Corn starch | Gluconate Calcium | DL-Lysine |
| Related Compound Libraries | Bioactive Compound Library | Pain-Related Compound Library | Anti-Neurodegenerative Disease Compound Library | Traditional Chinese Medicine Monomer Library | Drug Repurposing Compound Library | Natural Product Library | FDA-Approved Drug Library | Anti-Cancer Approved Drug Library | Immunology/Inflammation Compound Library | Human Endogenous Metabolite Library | Food as Medicine Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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