hMAO-B-IN-2 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-27 |
Product Details
| Product Name: hMAO-B-IN-2 | CAS No.: 2454459-87-9 |
| Supply Ability: 10g | Release date: 2025/10/27 |
Product Introduction
Bioactivity
| Name | hMAO-B-IN-2 |
| Description | hMAO-B-IN-2 (compound 6j) is an orally active, potent, selective, BBB-penetrating, and competitively reversible inhibitor of hMAO-B (IC50 = 4 nM) used in Alzheimer's disease research. hMAO-B-IN-2 exhibits good neuroprotective effects and low toxicity in SH-SY5Y cells [1]. |
| In vitro | hMAO-B-IN-2 (compound 6j) exhibits significant inhibitory activity across concentrations (0-100 μM), with IC50 values of 4 nM for hMAO-B and 6.04 nM for hMAO-A. As a reversible inhibitor of MAO-B, enzyme activity is largely recoverable after dilution to 0.1 × IC50 and 1 × IC50, showing approximately 82% and 45% activity restoration, respectively. At 25 μM over 48 hours, hMAO-B-IN-2 significantly inhibits MAO-B and reduces Aβ self-induced aggregation by 40.78 ± 6.27%. Furthermore, in SH-SY5Y neuroblastoma cells, it promotes cell survival in a dose-dependent manner without toxicity at concentrations up to 25 μM over 24 hours, highlighting its potential against neurodegenerative diseases. |
| In vivo | Compound hMAO-B-IN-2 (6j), administered to male Sprague-Dawley rats at doses of 3 mg/kg intravenously (IV) and 10 mg/kg orally (PO), exhibits satisfactory pharmacokinetic properties, including a high peak concentration (Cmax), a suitable half-life (T 1/2), and favorable oral bioavailability (F%). Specifically, the intravenous administration resulted in a peak concentration of 639.29 ± 89.06 μg/L, a half-life of approximately 1.02 ± 0.17 hours, and a clearance rate of 3.33 ± 0.15 L/h/kg. Oral administration showed a peak concentration of 142.17 ± 72.21 μg/L, a half-life of 1.33 ± 0.16 hours, and an oral bioavailability of 36.10%. These findings underscore the compound's efficacy and its potential for further pharmacological development. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Inhibitors Related | Rosmarinic acid | Safinamide | Indazole | 1,4-Naphthoquinone | Paeonol | Hydroxylamine hydrochloride | Isatin | Methylene Blue | Pargyline hydrochloride | β-Aminopropionitrile | Methylene Blue trihydrate | Amitraz |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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