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Postion:Product Catalog >Biochemical Engineering>Amino Acids and Derivatives>Tryptophan derivatives>L-5-Hydroxytryptophan
L-5-Hydroxytryptophan
  • L-5-Hydroxytryptophan

L-5-Hydroxytryptophan NEW

Price $5 $4 $2
Package 1kg 10kg 100kg
Min. Order: 1kg
Supply Ability: 100kg
Update Time: 2025-07-08

Product Details

Product Name: L-5-Hydroxytryptophan CAS No.: 4350-09-8
Min. Order: 1kg Purity: 99%
Supply Ability: 100kg Release date: 2025/07/08
Lead time: in stock Packaging: bag/bottle/drum//IBC, as request
Delivery: By sea, by air, by express Origin: Manufacturer, advantage products
COA, MSDS: Available, contact us for details Contact: Tina

PRODUCT INFORMATION

Names

Name5-hydroxy-L-tryptophan
SynonymMore Synonyms

 L-5-Hydroxytryptophan Biological Activity

DescriptionL-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, is the immediate precursor of the neurotransmitter serotonin and a reserpine antagonist[1]. L-5-Hydroxytryptophan (L-5-HTP) is used to treat fibromyalgia, myoclonus, migraine, and cerebellar ataxia[2][3][4][5].
Related Catalog
Research Areas >> Metabolic Disease
Research Areas >> Neurological Disease
Target

Human Endogenous Metabolite

References

[1]. ARVID CARLSSON, et al. 3,4-Dihydroxyphenylalanine and 5-Hydroxytryptophan as Reserpine Antagonists. Nature 180, page1200 (1957).

[2]. Caruso I, et al. Double-blind study of 5-hydroxytryptophan versus placebo in the treatment of primary fibromyalgia syndrome. J Int Med Res. 1990 May-Jun;18(3):201-9.

[3]. Thal LJ, et al. Treatment of myoclonus with L-5-hydroxytryptophan and carbidopa: clinical, electrophysiological, and biochemical observations. Ann Neurol. 1980 Jun;7(6):570-6.

[4]. Boiardi A, et al. 5-OH-Tryptophane in migraine: clinical and neurophysiological considerations. J Neurol. 1981;225(1):41-6.

[5]. Trouillas P, et al. Improvement of cerebellar ataxia with levorotatory form of 5-hydroxytryptophan. A double-blind study with quantified data processing. Arch Neurol. 1988 Nov;45(11):1217-22.

 Chemical & Physical Properties

Density1.5±0.1 g/cm3
Boiling Point520.6±50.0 °C at 760 mmHg
Melting Point270 °C (dec.)(lit.)
Molecular FormulaC11H12N2O3
Molecular Weight220.22
Flash Point268.7±30.1 °C
Exact Mass220.084793
PSA99.34000
LogP-0.14
Vapour Pressure0.0±1.4 mmHg at 25°C
Index of Refraction1.737
Water SolubilitySlightly soluble

 MSDS

L-5-Hydroxytryptophan MSDS(Chinese)

 Toxicological Information

CHEMICAL IDENTIFICATION

  • RTECS NUMBER :

  • YN7110000

  • CHEMICAL NAME :

  • Tryptophan, 5-hydroxy-, L-

  • CAS REGISTRY NUMBER :

  • 4350-09-8

  • BEILSTEIN REFERENCE NO. :

  • 0088200

  • LAST UPDATED :

  • 199712

  • DATA ITEMS CITED :

  • 19

  • MOLECULAR FORMULA :

  • C11-H12-N2-O3

  • MOLECULAR WEIGHT :

  • 220.25

  • WISWESSER LINE NOTATION :

  • T56 BMJ D1YZVQ GQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 243 mg/kg

  • TOXIC EFFECTS :

  • Behavioral - somnolence (general depressed activity) Behavioral - excitement Behavioral - ataxia

  • REFERENCE :

  • NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 69,523,1973

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 91 mg/kg

  • TOXIC EFFECTS :

  • Behavioral - somnolence (general depressed activity) Behavioral - excitement Behavioral - ataxia

  • REFERENCE :

  • NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 69,523,1973

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Subcutaneous

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 149 mg/kg

  • TOXIC EFFECTS :

  • Sense Organs and Special Senses (Eye) - lacrimation Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

  • REFERENCE :

  • IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,307,1975

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intravenous

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 27 mg/kg

  • TOXIC EFFECTS :

  • Sense Organs and Special Senses (Eye) - lacrimation Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

  • REFERENCE :

  • IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,307,1975

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 1708 mg/kg

  • TOXIC EFFECTS :

  • Sense Organs and Special Senses (Eye) - lacrimation Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

  • REFERENCE :

  • IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,307,1975

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 298 mg/kg

  • TOXIC EFFECTS :

  • Sense Organs and Special Senses (Eye) - lacrimation Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

  • REFERENCE :

  • IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,307,1975

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Subcutaneous

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 418 mg/kg

  • TOXIC EFFECTS :

  • Sense Organs and Special Senses (Eye) - lacrimation Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

  • REFERENCE :

  • IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,307,1975

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intravenous

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 375 mg/kg

  • TOXIC EFFECTS :

  • Behavioral - somnolence (general depressed activity) Behavioral - excitement Behavioral - ataxia

  • REFERENCE :

  • NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 69,523,1973

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - rabbit

  • DOSE/DURATION :

  • 285 mg/kg

  • TOXIC EFFECTS :

  • Sense Organs and Special Senses (Eye) - lacrimation Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

  • REFERENCE :

  • IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,307,1975 ** OTHER MULTIPLE DOSE TOXICITY DATA **

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 780 mg/kg/30D-C

  • TOXIC EFFECTS :

  • Kidney, Ureter, Bladder - other changes Kidney, Ureter, Bladder - changes in bladder weight Endocrine - changes in thymus weight

  • REFERENCE :

  • IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,307,1975

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 5148 mg/kg/26W-I

  • TOXIC EFFECTS :

  • Kidney, Ureter, Bladder - other changes Endocrine - other changes Related to Chronic Data - changes in testicular weight

  • REFERENCE :

  • IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,307,1975 ** REPRODUCTIVE DATA **

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • DOSE :

  • 700 mg/kg

  • SEX/DURATION :

  • female 7-13 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Maternal Effects - other effects Nutritional and Gross Metabolic - weight loss or decreased weight gain

  • REFERENCE :

  • IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,356,1975

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • DOSE :

  • 700 mg/kg

  • SEX/DURATION :

  • female 7-13 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - musculoskeletal system

  • REFERENCE :

  • IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,356,1975

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • DOSE :

  • 3 gm/kg

  • SEX/DURATION :

  • female 6-15 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - urogenital system

  • REFERENCE :

  • TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 27,85A,1983

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • DOSE :

  • 3 gm/kg

  • SEX/DURATION :

  • female 6-15 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

  • REFERENCE :

  • NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB83-231332

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • DOSE :

  • 2100 mg/kg

  • SEX/DURATION :

  • female 7-13 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Maternal Effects - other effects Nutritional and Gross Metabolic - weight loss or decreased weight gain

  • REFERENCE :

  • IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,356,1975

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • DOSE :

  • 2100 mg/kg

  • SEX/DURATION :

  • female 7-13 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death

  • REFERENCE :

  • IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,356,1975

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • DOSE :

  • 700 mg/kg

  • SEX/DURATION :

  • female 7-13 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Specific Developmental Abnormalities - musculoskeletal system

  • REFERENCE :

  • IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,356,1975

 Safety Information

SymbolArticle illustration
GHS06
Signal WordDanger
Hazard StatementsH301-H315-H319-H335
Precautionary StatementsMissing Phrase - N15.00950417-P305 + P351 + P338
Personal Protective Equipmentdust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard CodesXn:Harmful;
Risk PhrasesR22
Safety PhrasesS36-S26
RIDADRUN 2811 6.1/PG 3
WGK Germany3
RTECSYN7110000
Packaging GroupIII
Hazard Class6.1
HS Code2929909090

 Synthetic Route

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 Precursor & DownStream

Precursor  6

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  • Article illustration CAS#:90830-06-1
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  • Article illustration CAS#:73-22-3
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DownStream  2


  • Article illustration CAS#:50-67-9
    5-Hydroxytryptamine

  • Article illustration CAS#:119768-45-5
    6-(4,4,5,5-TETR...

 Customs

HS Code2933990090
Summary2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%


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Company Profile Introduction

Our company is a high-tech enterprise specializing in chemical raw materials such as electronic materials, optoelectronic materials, semiconductor materials, UV monomers, silane catalysts, cosmetic raw materials, etc. The company integrates research and development, production, customized synthesis, and sales, and is committed to providing customers with high-quality chemical product solutions. With our agile custom synthesis capabilities and responsive supply chain system, our products have gained widespread adoption across Asian markets including Japan, South Korea, Singapore, and Malaysia, while also expanding deeply into Europe and the Americas. We have forged long-term strategic partnerships with numerous leading global enterprises in the sector. "Driving value through technology and earning trust through service" is our core mission. Looking ahead, we will continue to focus on technological breakthroughs and green innovation in new materials, collaborating with partners to build a high-quality industrial ecosystem and provide globally competitive solutions with greater foresight.

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