L-Carnosine NEW

99% L-Carnosine CAS:305-84-0 anti-aging

Product Name:L-Carnosine

Synonyms:N-B-ALANYL-L-HISTIDINE;H-BETA-ALA-HIS-OH;L-IGNOTINE;L-BETA-ALANINE HISTIDINE;L-CARNOSINE;B-ALANYL-L-HISTIDINE;BETA-A-H;BETA-ALANYL-L-HISTIDINE

CAS:305-84-0

MF:C9H14N4O3

MW:226.23

EINECS:  206-169-9

Melting point:253 °C (dec.) (lit.)

alpha:20.9 º (c=1.5, H2O)

Boiling point:367.84°C (rough estimate)

density:1.2673 (rough estimate)

vapor pressure:0Pa at 25℃

refractive index:21 ° (C=2, H2O)

storage temp.:-20°C

solubility:DMSO (Very Slightly), Water (Slightly)

Chemical Properties:white to off-white crystalline.

Description   

L-Carnosine is a dipeptide composed of β-alanine and L-histidine that has been found in rat olfactory bulb, skeletal muscle, brain, kidney, and spleen tissues, as well as human skeletal muscle, and has diverse biological activities. It is a metal chelator that forms complexes with copper, cobalt, nickel, cadmium, or zinc. Dietary administration of L-carnosine (60 mg/kg per day) reduces plasma levels of advanced glycation end products (AGEs) in diabetic rats. It reduces brain edema, blood-brain barrier disruption, microglial activation, and neuronal apoptosis in a rat model of intracerebral hemorrhage when administered at a dose of 1,000 mg/kg. L-Carnosine (250, 500, and 1,000 mg/kg, i.p.) reduces hepatic protein carbonylation and necrosis in a rat model of cirrhosis induced by bile duct ligation. It also reduces lung myeloperoxidase (MPO) activity, production of reactive oxygen species (ROS), and TNF-α and IL-6 levels, as well as alveolar hemorrhage, interstitial edema, and pulmonary leukocyte infiltration in a mouse model of LPS-induced lung injury.