LYN-1604 hydrochloride NEW
| Price | $1152 | $2117 |
| Package | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-27 |
Product Details
| Product Name: LYN-1604 hydrochloride | CAS No.: 2216753-86-3 |
| Supply Ability: 10g | Release date: 2025/10/27 |
Product Introduction
Bioactivity
| Name | LYN-1604 hydrochloride |
| Description | LYN-1604 hydrochloride, a powerful activator of UNC-51-like kinase 1 (ULK1) with an EC50 value of 18.94 nM, has significant implications in the study of triple-negative breast cancer (TNBC). |
| In vitro | LYN-1604, identified as a potential ULK1 agonist, demonstrates enhanced enzymatic activity (195.7% at 100 nM) and exhibits a half-maximal inhibitory concentration (IC50) of 1.66 μM against MDA-MB-231 cells. It binds to the wild-type ULK1 with a nanomolar affinity (KD = 291.4 nM). At varying concentrations (0.5, 1.0, and 2.0 μM), LYN-1604 triggers cell death through the ULK complex in MDA-MB-231 cells and induces dose-dependent autophagy, evidenced by a notable increase in Beclin-1 expression, p62 degradation, and conversion of LC3-I to LC3-II. Additionally, it promotes ATG5-dependent autophagy via the ULK complex and facilitates apoptosis through increased caspase-3 cleavage. Cell viability assays and Western blot analyses further confirm these effects, showing dose-dependent induced cell death and autophagy, alongside the up-regulation of Beclin-1, degradation of p62, and LC3-I to LC3-II transformation, after a 24-hour incubation with LYN-1604. |
| In vivo | LYN-1604, administered intragastrically at various doses (low dose, 25 mg/kg; median dose, 50 mg/kg; high dose, 100 mg/kg) once daily for 14 days, significantly inhibits the growth of xenograft triple-negative breast cancer (TNBC) by targeting ULK1-modulated cell death, as demonstrated in an animal model using 24 female nude mice (BALB/c, 6-8 weeks, 20-22 g). The study reports no change in the body weights of mice across all doses, indicating a lack of systemic toxicity. However, a slight increase in liver and spleen weight indexes was observed in some groups, while the kidney weight index remained unaffected across all dose groups. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | LYN1604 Hydrochloride | LYN1604 hydrochloride | LYN 1604 hydrochloride | LYN-1604 Hydrochloride | LYN 1604 Hydrochloride |
| Inhibitors Related | Stavudine | Aceglutamide | Cysteamine hydrochloride | Hydroxychloroquine | Metronidazole | Guanidine hydrochloride | Citric Acid Triammonium | Tributyrin | Paeonol | Naringin | Alginic acid | Dextran sulfate sodium salt (MW 5000) |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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