Melitracen Impurity NEW

Melitracen Impurity;5447-86-9

WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com

Product Information (M093001)

• Product Code：M093001

• English Name：Melitracen Impurity 1

• English Alias：10,10-dimethylanthracen-9(10H)-one

• CAS No.：5447-86-9

• Molecular Formula：C₁₆H₁₄O

• Molecular Weight：222.28

Advantages (M093001)

• High-Purity Reference Standard：Confirmed by HPLC (≥99.0%), NMR (1H, 13C), HRMS, and elemental analysis, suitable for Melitracen impurity analysis and quality control.

• Stability Assurance：Stable for 36 months at -20℃ under light-protected, sealed storage; degradation rate <0.3% in common solvents like methanol and acetonitrile within 6 months.

Applications (M093001)

• Quality Control Testing：Used for UPLC-MS/MS detection of Impurity 1 in Melitracen API and formulations, controlling content to meet ICH Q3A standards (single impurity limit ≤0.1%).

• Process Optimization Research：Monitors impurity formation during Melitracen synthesis, reducing generation by >30% by adjusting condensation temperature (e.g., 60-70℃) and catalyst dosage.

• Method Validation：Serves as a standard for developing impurity detection methods, verifying UPLC resolution (≥3.0) and LOD (0.01 ng/mL).

Background Description (M093001)

Research Status (M093001)

• Detection Technology：UPLC-MS/MS with C18 column (1.7μm) and 0.1% formic acid-acetonitrile gradient elution achieves separation within 5 minutes, with LOD of 0.003 ng/mL for high-precision trace impurity analysis.

• Formation Mechanism：Formed by oxidation of 10,10-dimethylanthracene with oxidants (e.g., manganese dioxide); optimizing oxidant dosage and reaction time reduces by-product generation.

• Safety Evaluation：In vitro cytotoxicity shows IC₅₀ of 205.6 μM against SH-SY5Y cells (Melitracen IC₅₀=11.3 μM), with lower toxicity than the main drug but requiring strict content control. Long-term stability testing is ongoing to monitor degradation under light and high-temperature conditions.

NOTE！

We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!

WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com

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The Molcoo Laboratory added drug impurity reference standards, including Baricitinib, Piperazine, Benzylpenicillin, Tranilast and multiple N-Nitroso drug impurities! Now available for immediate delivery!